Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Relation of osteoprotegerin in severe aortic valve stenosis to postoperative outcome and left ventricular function

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Causes of Mortality in the Marfan Syndrome(from a Nationwide Register Study)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Usefulness of Transcatheter Aortic Valve Implantation for Treatment of Pure Native Aortic Valve Regurgitation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mechanical circulatory support for decompensated heart failure: the last remaining indication for intra-aortic balloon pump?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Rationale and design of DanGer shock: Danish-German cardiogenic shock trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Empagliflozin in heart failure patients with reduced ejection fraction: a randomized clinical trial (Empire HF)

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Central and Peripheral Determinants of Exercise Capacity in Heart Failure Patients With Preserved Ejection Fraction

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Left Atrial Function in Heart Failure With Reduced Ejection Fraction

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jordi Dahl
  • Lars Videbæk
  • Mikael Kjær Poulsen
  • Torsten R Rudbaek
  • Nicolaj L Christensen
  • Patricia A Pellikka
  • Lars Melholt Rasmussen
  • Jacob E Møller
View graph of relations
Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and is known to be among the mediators of the calcification process that has been shown to increase in patients with aortic stenosis (AS). The aim of this study was to characterize the association of OPG with left ventricular (LV) function and remodeling and to evaluate the significance of preoperative OPG on long-term outcome in terms of survival and symptomatic improvement in 124 patients with severe AS scheduled for aortic valve replacement (AVR). Patients were divided according to tertiles of preoperative OPG. Preoperative OPG was associated with age, EuroSCORE, and preoperative functional capacity. Despite similar ejection fraction and diastolic function among groups, longitudinal LV systolic function consistently decreased and markers of filling pressure increased across groups. During median follow-up of 4 years, 41 patients died of a presumed cardiovascular cause or remained in New York Heart Association functional class III or IV. The risk of a poor postoperative outcome after AVR increased with increasing OPG tertiles (15% vs 33% vs 51%, p = 0.002). In a multivariate model containing age, ejection fraction, N-terminal pro-brain natriuretic peptide and left atrial volume index, OPG was still significantly associated with postoperative outcome. In addition, OPG levels associated with cardiovascular mortality during follow-up. In conclusion, OPG is associated with LV and left atrial remodeling in patients with symptomatic severe AS undergoing AVR. Moreover, plasma OPG is associated with long-term postoperative outcome and may identify patients with poor symptomatic improvement after surgery.
Original languageEnglish
JournalThe American journal of cardiology
Volume112
Issue number9
Pages (from-to)1433-8
Number of pages6
ISSN0002-9149
DOIs
Publication statusPublished - 1 Nov 2013

    Research areas

  • Aged, Aortic Valve Stenosis, Female, Follow-Up Studies, Heart Valve Prosthesis, Humans, Male, Osteoprotegerin, Postoperative Period, Prospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome, Ventricular Function, Left, Ventricular Remodeling

ID: 42943887