Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Add-on therapy in metformin-treated patients with type 2 diabetes at moderate cardiovascular risk: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Heart failure and the prognostic impact and incidence of new-onset of diabetes mellitus: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Interleukin-6 may not affect bone resorption marker CTX or bone formation marker P1NP in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total amount of cardiac adipose tissue was associated with coronary artery calcium score (CAC) and myocardial flow reserve in persons with type 1 or type 2 diabetes and healthy controls.

METHODS: We studied three groups: (1) 30 controls, (2) 60 persons with type 1 diabetes and (3) 60 persons with type 2 diabetes. The three groups were matched for sex and age. The three groups derived from retrospective analysis of two clinical studies. All underwent cardiac 82Rb positron emission tomography/computed tomography (PET/CT) scanning. Cardiac adipose tissue volume (the sum of epicardial and pericardial fat), CAC, and myocardial flow reserve (ratio of pharmacological stress flow and rest flow) were evaluated using semiautomatic software. We applied linear regression to assess the association between cardiac adipose tissue, CAC and myocardial flow reserve.

RESULTS: Mean (SD) cardiac adipose tissue volume was 99 (61) mL in the control group, 106 (78) mL in the type 1 diabetes group and 228 (97) mL in the type 2 diabetes group. Cardiac adipose tissue was positively associated with body mass index in all three groups (p ≤ 0.02). In the controls, cardiac adipose tissue was positively associated with CAC score (p = 0.008) and negatively associated with myocardial flow reserve (p = 0.005). However, cardiac adipose tissue was not associated with CAC or myocardial flow reserve in the groups including persons with type 1 or type 2 diabetes (p ≥ 0.50).

CONCLUSIONS: In contrast to what was found in healthy controls, we could not establish a relation between cardiac adipose tissue and coronary calcification or myocardial microvascular function in person with type 1 or type 2 diabetes. The role of cardiac adipose tissue in cardiovascular disease in diabetes remains unclear.

Original languageEnglish
Article number16
JournalCardiovascular Diabetology
Volume19
Issue number1
ISSN1475-2840
DOIs
Publication statusPublished - 10 Feb 2020

ID: 59293325