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Rigshospitalet - a part of Copenhagen University Hospital
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Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation

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The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.

Original languageEnglish
JournalAmerican Journal of Cardiology
Volume96
Issue number3
Pages (from-to)405-7
Number of pages3
ISSN0002-9149
DOIs
Publication statusPublished - 1 Aug 2005

    Research areas

  • Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Case-Control Studies, Chi-Square Distribution, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Potassium Channels, Voltage-Gated, Risk Assessment, Journal Article, Research Support, Non-U.S. Gov't

ID: 32554047