Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Regulation of blood volume in lowlanders exposed to high altitude

Research output: Contribution to journalReviewpeer-review

  1. Effects of strict prolonged bed rest on cardiorespiratory fitness: systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. CORP: The assessment of total hemoglobin mass by carbon monoxide rebreathing

    Research output: Contribution to journalReviewpeer-review

  3. Leg blood flow is impaired during small muscle mass exercise in patients with COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Induction of erythroferrone in healthy humans by micro-dose recombinant erythropoietin or high-altitude exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The interaction between metformin and physical activity on postprandial glucose and glucose kinetics: a randomised, clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Did you know-why does maximal oxygen uptake increase in humans following endurance exercise training?

    Research output: Contribution to journalEditorialpeer-review

  5. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Humans ascending to high altitude (HA) experience a reduction in arterial oxyhemoglobin saturation and, as a result, arterial O2 content ([Formula: see text]). As HA exposure extends, this reduction in [Formula: see text] is counteracted by an increase in arterial hemoglobin concentration. Initially, hemoconcentration is exclusively related to a reduction in plasma volume (PV), whereas after several weeks a progressive expansion in total red blood cell volume (RCV) contributes, although often to a modest extent. Since the decrease in PV is more rapid and usually more pronounced than the expansion in RCV, at least during the first weeks of exposure, a reduction in circulating blood volume is common at HA. Although the regulation of hematological responses to HA has been investigated for decades, it remains incompletely understood. This is not only related to the large number of mechanisms that could be involved and the complexity of their interplay but also to the difficulty of conducting comprehensive experiments in the often secluded HA environment. In this review, we present our understanding of the kinetics, the mechanisms and the physiological relevance of the HA-induced reduction in PV and expansion in RCV.

Original languageEnglish
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Volume123
Issue number4
Pages (from-to)957-966
Number of pages10
ISSN8750-7587
DOIs
Publication statusPublished - 1 Oct 2017

    Research areas

  • Journal Article, Review

ID: 52608302