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Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors

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Harvard

Vachon, H, Mierzynska, J, Taye, M, Pe, M, Coens, C, Martinelli, F, Fortpied, C, Flechtner, H-H, Maraldo, MV, Hutchings, M, Meijnders, P, Aleman, B, Lugtenburg, P, Spina, M, André, M, Hertzberg, M, Briones, J, Bottomley, A & EORTC Quality of Life Group, Lymphoma Group 2021, 'Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors', European Journal of Haematology, vol. 106, no. 5, pp. 697-707. https://doi.org/10.1111/ejh.13601

APA

Vachon, H., Mierzynska, J., Taye, M., Pe, M., Coens, C., Martinelli, F., Fortpied, C., Flechtner, H-H., Maraldo, M. V., Hutchings, M., Meijnders, P., Aleman, B., Lugtenburg, P., Spina, M., André, M., Hertzberg, M., Briones, J., Bottomley, A., & EORTC Quality of Life Group, Lymphoma Group (2021). Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors. European Journal of Haematology, 106(5), 697-707. https://doi.org/10.1111/ejh.13601

CBE

Vachon H, Mierzynska J, Taye M, Pe M, Coens C, Martinelli F, Fortpied C, Flechtner H-H, Maraldo MV, Hutchings M, Meijnders P, Aleman B, Lugtenburg P, Spina M, André M, Hertzberg M, Briones J, Bottomley A, EORTC Quality of Life Group, Lymphoma Group. 2021. Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors. European Journal of Haematology. 106(5):697-707. https://doi.org/10.1111/ejh.13601

MLA

Vancouver

Author

Vachon, Hugo ; Mierzynska, Justyna ; Taye, Mekdes ; Pe, Madeline ; Coens, Corneel ; Martinelli, Francesca ; Fortpied, Catherine ; Flechtner, Henning-Hans ; Maraldo, Maja Vestmoe ; Hutchings, Martin ; Meijnders, Paul ; Aleman, Berthe ; Lugtenburg, Pieternella ; Spina, Michele ; André, Marc ; Hertzberg, Mark ; Briones, Javier ; Bottomley, Andrew ; EORTC Quality of Life Group, Lymphoma Group. / Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors. In: European Journal of Haematology. 2021 ; Vol. 106, No. 5. pp. 697-707.

Bibtex

@article{0c207dfe29db48f2b375594cf106b219,
title = "Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors",
abstract = "OBJECTIVES: To provide reference values for the European Organisation for Treatment and Research of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) in advanced-stage Hodgkin lymphoma (HL) patients and 5-year HL survivors. The QLQ-C30 is the most widely used cancer-specific questionnaire to assess Health-Related Quality of Life (HRQoL).METHODS: The EORTC database was searched to identify HL RCTs in which patients' and survivors' HRQoL was assessed by the QLQ-C30. HRQoL mean scores were calculated and stratified by age and gender. Minimal important differences were used to assess the clinical relevance of the findings. Data from one RCT with HRQoL scores available at baseline (n = 343) and four RCTs with HRQoL scores available at follow-up (n = 1665) were analyzed.RESULTS: Patients reported worse HRQoL scores than survivors across most functioning scales and symptoms' scales. These scores varied as a function of gender but not age. Survivors' HRQoL reports were comparable to the ones of the general population.CONCLUSIONS: These values provide an assessment framework for the comparison and interpretation of QLQ-C30 scores in advanced-stage HL. Our findings suggest that although HL patients' HRQoL scores are worse than the general population, HRQoL scores may normalize over long-term survival.",
keywords = "EORTC QLQ-C30, Hodgkin lymphoma - survivor, quality of life, reference values, C30, EORTC QLQ&#8208, Hodgkin lymphoma &#8208, survivor",
author = "Hugo Vachon and Justyna Mierzynska and Mekdes Taye and Madeline Pe and Corneel Coens and Francesca Martinelli and Catherine Fortpied and Henning-Hans Flechtner and Maraldo, {Maja Vestmoe} and Martin Hutchings and Paul Meijnders and Berthe Aleman and Pieternella Lugtenburg and Michele Spina and Marc Andr{\'e} and Mark Hertzberg and Javier Briones and Andrew Bottomley and {EORTC Quality of Life Group, Lymphoma Group}",
note = "{\textcopyright} 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2021",
month = may,
doi = "10.1111/ejh.13601",
language = "English",
volume = "106",
pages = "697--707",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Munksgaard",
number = "5",

}

RIS

TY - JOUR

T1 - Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors

AU - Vachon, Hugo

AU - Mierzynska, Justyna

AU - Taye, Mekdes

AU - Pe, Madeline

AU - Coens, Corneel

AU - Martinelli, Francesca

AU - Fortpied, Catherine

AU - Flechtner, Henning-Hans

AU - Maraldo, Maja Vestmoe

AU - Hutchings, Martin

AU - Meijnders, Paul

AU - Aleman, Berthe

AU - Lugtenburg, Pieternella

AU - Spina, Michele

AU - André, Marc

AU - Hertzberg, Mark

AU - Briones, Javier

AU - Bottomley, Andrew

AU - EORTC Quality of Life Group, Lymphoma Group

N1 - © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2021/5

Y1 - 2021/5

N2 - OBJECTIVES: To provide reference values for the European Organisation for Treatment and Research of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) in advanced-stage Hodgkin lymphoma (HL) patients and 5-year HL survivors. The QLQ-C30 is the most widely used cancer-specific questionnaire to assess Health-Related Quality of Life (HRQoL).METHODS: The EORTC database was searched to identify HL RCTs in which patients' and survivors' HRQoL was assessed by the QLQ-C30. HRQoL mean scores were calculated and stratified by age and gender. Minimal important differences were used to assess the clinical relevance of the findings. Data from one RCT with HRQoL scores available at baseline (n = 343) and four RCTs with HRQoL scores available at follow-up (n = 1665) were analyzed.RESULTS: Patients reported worse HRQoL scores than survivors across most functioning scales and symptoms' scales. These scores varied as a function of gender but not age. Survivors' HRQoL reports were comparable to the ones of the general population.CONCLUSIONS: These values provide an assessment framework for the comparison and interpretation of QLQ-C30 scores in advanced-stage HL. Our findings suggest that although HL patients' HRQoL scores are worse than the general population, HRQoL scores may normalize over long-term survival.

AB - OBJECTIVES: To provide reference values for the European Organisation for Treatment and Research of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) in advanced-stage Hodgkin lymphoma (HL) patients and 5-year HL survivors. The QLQ-C30 is the most widely used cancer-specific questionnaire to assess Health-Related Quality of Life (HRQoL).METHODS: The EORTC database was searched to identify HL RCTs in which patients' and survivors' HRQoL was assessed by the QLQ-C30. HRQoL mean scores were calculated and stratified by age and gender. Minimal important differences were used to assess the clinical relevance of the findings. Data from one RCT with HRQoL scores available at baseline (n = 343) and four RCTs with HRQoL scores available at follow-up (n = 1665) were analyzed.RESULTS: Patients reported worse HRQoL scores than survivors across most functioning scales and symptoms' scales. These scores varied as a function of gender but not age. Survivors' HRQoL reports were comparable to the ones of the general population.CONCLUSIONS: These values provide an assessment framework for the comparison and interpretation of QLQ-C30 scores in advanced-stage HL. Our findings suggest that although HL patients' HRQoL scores are worse than the general population, HRQoL scores may normalize over long-term survival.

KW - EORTC QLQ-C30

KW - Hodgkin lymphoma - survivor

KW - quality of life

KW - reference values

KW - C30

KW - EORTC QLQ&#8208

KW - Hodgkin lymphoma &#8208

KW - survivor

U2 - 10.1111/ejh.13601

DO - 10.1111/ejh.13601

M3 - Journal article

C2 - 33570765

VL - 106

SP - 697

EP - 707

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 5

ER -

ID: 62111053