Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Reference equations for pulmonary diffusing capacity of carbon monoxide and nitric oxide in adult Caucasians

Research output: Contribution to journalJournal articleResearchpeer-review

  1. NORDSTAR - Paving the way for a new era in asthma research

    Research output: Contribution to journalEditorialResearchpeer-review

  2. ERS/TSANZ Task Force Statement on the Management of Reproduction and Pregnancy in Women with Airways Diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Latent tuberculosis infection among minor asylum seekers in Denmark

    Research output: Contribution to journalLetterResearchpeer-review

  4. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

The aim of this study was to determine reference equations for the combined measurement of diffusing capacity of the lung for carbon monoxide (CO) and nitric oxide (NO) (DLCONO). In addition, we wanted to appeal for consensus regarding methodology of the measurement including calculation of diffusing capacity of the alveolo-capillary membrane (Dm) and pulmonary capillary volume (Vc).DLCONO was measured in 282 healthy individuals aged 18-97 years using the single-breath technique and a breath-hold time of 5 s (true apnoea period). The following values were used: 1) specific conductance of nitric oxide (θNO)=4.5 mLNO·mLblood-1·min-1·mmHg-1; 2) ratio of diffusing capacity of the membrane for NO and CO (DmNO/DmCO)=1.97; and 3) 1/red cell CO conductance (1/θCO)=(1.30+0.0041·mean capillary oxygen pressure)·(14.6/Hb concentration in g·dL-1).Reference equations were established for the outcomes of DLCONO, including DLCO and DLNO and the calculated values Dm and Vc Independent variables were age, sex, height and age squared.By providing new reference equations and by appealing for consensus regarding the methodology, we hope to provide a basis for future studies and clinical use of this novel and interesting method.

Original languageEnglish
JournalThe European Respiratory Journal
Volume52
Issue number1
Pages (from-to)1500677
ISSN0903-1936
DOIs
Publication statusPublished - Jul 2018

ID: 56620186