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Rigshospitalet - a part of Copenhagen University Hospital
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Reduced levels of pulmonary surfactant in COVID-19 ARDS

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To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

Original languageEnglish
Article number4040
JournalScientific Reports
Volume12
Issue number1
Pages (from-to)1-5
Number of pages5
ISSN2045-2322
DOIs
Publication statusPublished - 8 Mar 2022

Bibliographical note

© 2022. The Author(s).

    Research areas

  • 1,2-Dipalmitoylphosphatidylcholine/analysis, Adult, Aged, Bronchoalveolar Lavage Fluid/chemistry, COVID-19/pathology, Case-Control Studies, Female, Humans, Male, Middle Aged, Principal Component Analysis, Pulmonary Surfactants/analysis, SARS-CoV-2/isolation & purification, Severity of Illness Index, Spectrophotometry, Infrared/methods

ID: 75596291