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Rigshospitalet - a part of Copenhagen University Hospital
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Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections

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DOI

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  2. Children exposed or unexposed to HIV: weight, height and BMI during the first five years of life. A Danish Nationwide Cohort Study

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  3. Varicella Zoster Virus encephalitis in Denmark from 2015 to 2019- A nationwide prospective cohort study

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  1. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

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  2. Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

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  3. Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

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  4. Evolutionary highways to persistent bacterial infection

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  • Antimicrobial Resistance International Working Group in Cystic Fibrosis
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Median cystic fibrosis (CF) survival has increased dramatically over time due to several factors, including greater availability and use of antimicrobial therapies. During the progression of CF lung disease, however, the emergence of multidrug antimicrobial resistance can limit treatment effectiveness, threatening patient longevity. Current planktonic-based antimicrobial susceptibility testing lacks the ability to predict clinical response to antimicrobial treatment of chronic CF lung infections. There are numerous reasons for these limitations including bacterial phenotypic and genotypic diversity, polymicrobial interactions, and impaired antibiotic efficacy within the CF lung environment. The parallels to other chronic diseases such as non-CF bronchiectasis are discussed as well as research priorities for moving forward.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume69
Issue number10
Pages (from-to)1812-1816
Number of pages5
ISSN1058-4838
DOIs
Publication statusPublished - 30 Oct 2019

ID: 59016550