Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Real-World Outcomes for 205 Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review

    Research output: Contribution to journalReviewResearchpeer-review

  1. Response to Aviv et al

    Research output: Contribution to journalLetterResearchpeer-review

  2. Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival

    Research output: Contribution to journalLetterResearchpeer-review

  • Kathrine Aarup
  • Emelie Curovic Rotbain
  • Lisbeth Enggaard
  • Robert Schou Pedersen
  • Olav Jonas Bergmann
  • Rasmus Heje Thomsen
  • Mikael Frederiksen
  • Henrik Frederiksen
  • Tine Nielsen
  • Ilse Christiansen
  • Michael Asger Andersen
  • Carsten Utoft Niemann
View graph of relations

Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front-line setting and as later-line treatment. However, knowledge about the outcomes and adverse events (AE) among patients at a population-based level is still limited. Objectives: To report outcomes and AEs in a population-based cohort treated with ibrutinib outside clinical trials. Methods: We conducted a multicenter, retrospective cohort study including all patients with CLL treated with ibrutinib. Results: In total, 205 patients were included of whom 39 (19%) were treatment-naïve. The median follow-up was 21.4 months (interquartile range (IQR), 11.9,32.8), the estimated overall survival at 12 months was 88.8% (95% confidence interval (CI); 84.3%, 93.3%), and the estimated progression-free survival at 12 months was 86.3% (95% CI; 81.3%, 91.2%). During follow-up, 200 (97.6%) patients had at least one AE and 100 (48.8%) patients had at least one grade ≥3 AE. Eighty-six patients (42.0%) discontinued ibrutinib, hereof 47 (54.7%) due to AEs and 19 (22.1%) had progression of CLL or Richter transformation. Conclusions: In our study, we find comparable, though slightly inferior, overall, and progression-free survival, and discontinuation due to toxicity was higher compared with clinical trials. Patient training and information may improve treatment adherence outside clinical trials.

Original languageEnglish
JournalEuropean Journal of Haematology
Volume105
Issue number5
Pages (from-to)646-654
Number of pages9
ISSN0902-4441
DOIs
Publication statusPublished - 1 Nov 2020

Bibliographical note

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

    Research areas

  • chronic lymphocytic leukemia, epidemiology, targeted therapy

ID: 60720386