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Readmission and death in patients admitted with new-onset versus worsening of chronic heart failure: insights from a nationwide cohort

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  • Jawad H Butt
  • Emil L Fosbøl
  • Thomas A Gerds
  • Charlotte Andersson
  • John J V McMurray
  • Mark C Petrie
  • Finn Gustafsson
  • Christian Madelaire
  • Søren Lund Kristensen
  • Gunnar H Gislason
  • Christian Torp-Pedersen
  • Lars Køber
  • Morten Schou
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AIMS: To examine the rates of all-cause mortality and heart failure (HF) readmission in patients hospitalized with decompensated HF according to HF duration - new-onset HF and worsening of chronic HF.

METHODS AND RESULTS: In this nationwide observational cohort study, 17 176 patients were included at first hospital admission for HF in the period 2013-2015 using data from Danish nationwide registries. In total, 8860 (51.6%) patients were admitted with new-onset HF and 8316 (48.4%) with worsening of chronic HF. Patients with worsening of chronic HF were characterized by a greater comorbidity burden compared with patients with new-onset HF. The rates of outcomes were examined by multivariable Cox regression models, adjusted for age, sex, and comorbidity. Worsening of chronic HF was associated with a higher rate of the composite endpoint of all-cause mortality or HF readmission [hazard ratio (HR) 1.37, 95% confidence interval (CI) 1.31-1.43], all-cause mortality (HR 1.22, 95% CI 1.16-1.28), and HF readmission (HR 1.81, 95% CI 1.69-1.93) compared with new-onset HF. There was an interaction between atrial fibrillation (AF), HF duration, and outcome: in worsening of chronic HF, the rate of the composite endpoint was higher in patients with AF compared with those without (HR 1.12, 95% CI 1.07-1.19), whereas in new-onset HF, the rate of the composite endpoint was lower in patients with AF compared with those without (HR 0.91, 95% CI 0.85-0.96) (P-value for interaction <0.001).

CONCLUSIONS: Among patients hospitalized with decompensated HF, worsening of chronic HF was associated with poorer outcomes compared with new-onset HF.

Original languageEnglish
JournalEuropean Journal of Heart Failure
Issue number10
Pages (from-to)1777-1785
Number of pages9
Publication statusPublished - 1 Oct 2020

    Research areas

  • Acute heart failure, All-cause mortality, Epidemiology, Heart failure readmission, New-onset heart failure, Worsening of chronic heart failure

ID: 59619899