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Rigshospitalet - a part of Copenhagen University Hospital
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Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers

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  1. Pharmacokinetic analysis of [68Ga]Ga-DOTA-TOC PET in meningiomas for assessment of in vivo somatostatin receptor subtype 2

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  2. In vivo imaging of cell proliferation in meningioma using 3'-deoxy-3'-[18F]fluorothymidine PET/MRI

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  3. High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma

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  4. Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain

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  5. Assessment of acute bone loading in humans using [18F]NaF PET/MRI

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  1. Blocking of efflux transporters in rats improves translational validation of brain radioligands

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  2. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women

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  3. Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol

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Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [(11)C]Cimbi-5 in different ways. Here, we present the in vivo validation of nine novel 5-HT(2A) receptor agonist PET tracers in the pig brain.
Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume38
Issue number4
Pages (from-to)681-93
Number of pages13
ISSN1619-7070
DOIs
Publication statusPublished - 2011

    Research areas

  • Animals, Biological Transport, Brain, Carbon Radioisotopes, Female, Humans, Hydrolysis, Injections, Intravenous, Ketanserin, Phenethylamines, Phosphatidylinositols, Positron-Emission Tomography, Radioactive Tracers, Radiochemistry, Receptor, Serotonin, 5-HT2A, Serotonin 5-HT2 Receptor Agonists, Swine

ID: 33245838