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Rigshospitalet
- a part of Copenhagen University Hospital
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Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers
Research output: Contribution to journal › Journal article › Research › peer-review
Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [(11)C]Cimbi-5 in different ways. Here, we present the in vivo validation of nine novel 5-HT(2A) receptor agonist PET tracers in the pig brain.
| Original language | English |
|---|---|
| Journal | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 38 |
| Issue number | 4 |
| Pages (from-to) | 681-93 |
| Number of pages | 13 |
| ISSN | 1619-7070 |
| DOIs | |
| Publication status | Published - 2011 |
- Animals, Biological Transport, Brain, Carbon Radioisotopes, Female, Humans, Hydrolysis, Injections, Intravenous, Ketanserin, Phenethylamines, Phosphatidylinositols, Positron-Emission Tomography, Radioactive Tracers, Radiochemistry, Receptor, Serotonin, 5-HT2A, Serotonin 5-HT2 Receptor Agonists, Swine
Research areas
ID: 33245838