Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Pupillary response to direct and consensual chromatic light stimuli

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Primary congenital glaucoma in Denmark, 1977-2016

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Evaluating an algorithm for screening intervals for diabetic retinopathy and the effect of HbA1c and hypertension

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Evaluation of a screening algorithm for detection of diabetic retinopathy based on quantitation of retinal pathological elements

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations

PURPOSE: To assess whether the direct and consensual postillumination (ipRGC-driven) pupil light responses to chromatic light stimuli are equal in healthy subjects.

METHODS: Pupil responses in healthy volunteers were recorded using a prototype binocular chromatic pupillometer (IdeaMedical, Copenhagen), which is capable of both direct and consensual pupillometry measurements. The device uses a pair of dual monochromatic narrow bandwidth LED light sources, red (660 nm) and blue (470 nm). Pupil light responses were recorded with infrared video cameras and analysed using custom-made circuitry and software. Subjects were randomized to receive light stimuli at either the right or left eye after 5 min of dark adaptation. Pupil light responses were recorded in both eyes for 10 seconds before illumination, during illumination and 50 seconds after illumination with red and blue light. Three variables were defined for the recorded pupil responses: the maximal constriction amplitude (CAmax ), the pupil response during illumination and postillumination pupil response (PIPR).

RESULTS: No difference was found in the pupil response to blue light. With red light, the pupil response during illumination was slightly larger during consensual illumination compared to direct illumination (0.54 and 0.52, respectively, p = 0.027, paired Wilcoxon's test, n = 12), while no differences were found for CAmax or the PIPR.

CONCLUSIONS: No difference was found between direct and consensual pupil response to either red or blue light in the postillumination period. Direct and consensual responses can readily be compared when examining the postillumination pupil response to blue light as estimation of photosensitive retinal ganglion cell activation.

Original languageEnglish
JournalActa Ophthalmologica
Volume94
Issue number1
Pages (from-to)65–69
ISSN1755-375X
DOIs
Publication statusPublished - 2016

ID: 45977378