Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation

Research output: Contribution to journalJournal articleResearchpeer-review

  1. In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lung clearance index-triggered intervention in children with cystic fibrosis - A randomised pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. First case of cystic fibrosis in Greenland - diagnosed by neonatal screening

    Research output: Contribution to journalLetterResearchpeer-review

  1. Intensive Care Antifungal Stewardship Programme Based on T2Candida PCR and Candida Mannan Antigen: A Prospective Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The evolution of the ISHLT transplant registry. Preparing for the future

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. First patient with ILNEB syndrome due to pathogenic variants in ITGA3 surviving to adulthood

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Specific Pseudomonas aeruginosa (PA) precipitating immunoglobulin G antibodies in serum are correlated with PA biofilm infection and are used as diagnostic and prognostic markers in cystic fibrosis (CF). The aim of this study was to examine the change of PA antibody response in CF patients after bilateral sequential lung transplantation (LTx).

METHODS: PA antibodies and airway bacteriology were retrospectively evaluated in 20 chronically infected CF patients, who underwent LTx between 2001 and 2016 at Rigshospitalet, Copenhagen. Yearly precipitin counts from one year before LTx and up to five years after LTx were compared. Monthly airway cultures were examined in the five-year period after LTx. In addition, crossed immunoelectrophoresis (CIE) were analysed for each patient for antigenic similarities from time of infection, pre-LTx and post-LTx.

RESULTS: All patients experienced a significant drop in PA antibodies from one year pre-LTx to one year post-LTx (p < 0.0001). The PA antibody level did not differ between those, who became reinfected immediately after LTx, and those, who did not. No patients regained the high pre-LTx precipitin levels in the following five years. The antigenic specificities of the sera post-LTx were in each patient similar to the antigenic specificities at the beginning of infection indicating a decades long memory of their immune response like an "immunological fingerprint".

CONCLUSIONS: After LTx a significant and continuous reduction in PA antibodies was observed. The reduction was independent of immediate reinfection after LTx. A novel three-factor explanatory model is presented.

Original languageEnglish
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume19
Issue number4
Pages (from-to)587-594
Number of pages8
ISSN1569-1993
DOIs
Publication statusPublished - Jul 2020

    Research areas

  • Cystic fibrosis, Humoral response, Lung transplantation, Pseudomonas aeruginosa

ID: 61985258