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Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

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Mygind, Naja Dam ; Nielsen, Signe Holm ; Michelsen, Marie Mide ; Pena, Adam ; Bechsgaard, Daria Frestad ; Suhrs, Elena ; Bove, Kira Bang ; Genovese, Federica ; Nielsen, Henning Bay ; Karsdal, Morten ; Vejlstrup, Niels ; Prescott, Eva ; Kastrup, Jens. / Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis : the iPOWER Study. In: Journal of Cardiovascular Translational Research. 2021.

Bibtex

@article{11dcd46dd0384b73acf70ab8f06b47dc,
title = "Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study",
abstract = "Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r 2 = 0.38, p<0.001 and r 2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.] ",
keywords = "Angina pectoris, Cardiac magnetic resonance, Coronary microvascular disease, Diffuse myocardial fibrosis, Extracellular matrix, Proteoglycan, T1 mapping",
author = "Mygind, {Naja Dam} and Nielsen, {Signe Holm} and Michelsen, {Marie Mide} and Adam Pena and Bechsgaard, {Daria Frestad} and Elena Suhrs and Bove, {Kira Bang} and Federica Genovese and Nielsen, {Henning Bay} and Morten Karsdal and Niels Vejlstrup and Eva Prescott and Jens Kastrup",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "1",
doi = "10.1007/s12265-021-10106-y",
language = "English",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer New York LLC",

}

RIS

TY - JOUR

T1 - Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis

T2 - the iPOWER Study

AU - Mygind, Naja Dam

AU - Nielsen, Signe Holm

AU - Michelsen, Marie Mide

AU - Pena, Adam

AU - Bechsgaard, Daria Frestad

AU - Suhrs, Elena

AU - Bove, Kira Bang

AU - Genovese, Federica

AU - Nielsen, Henning Bay

AU - Karsdal, Morten

AU - Vejlstrup, Niels

AU - Prescott, Eva

AU - Kastrup, Jens

N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r 2 = 0.38, p<0.001 and r 2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]

AB - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r 2 = 0.38, p<0.001 and r 2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]

KW - Angina pectoris

KW - Cardiac magnetic resonance

KW - Coronary microvascular disease

KW - Diffuse myocardial fibrosis

KW - Extracellular matrix

KW - Proteoglycan

KW - T1 mapping

UR - http://www.scopus.com/inward/record.url?scp=85101813100&partnerID=8YFLogxK

U2 - 10.1007/s12265-021-10106-y

DO - 10.1007/s12265-021-10106-y

M3 - Journal article

C2 - 33649986

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

ER -

ID: 64081685