Research output: Contribution to journal › Journal article › Research › peer-review
Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r 2 = 0.38, p<0.001 and r 2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling. Graphical abstract: [Figure not available: see fulltext.]
Original language | English |
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Journal | Journal of Cardiovascular Translational Research |
Volume | 14 |
Issue number | 5 |
Pages (from-to) | 921-929 |
Number of pages | 9 |
ISSN | 1937-5387 |
DOIs | |
Publication status | Published - Oct 2021 |
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
ID: 64081685