Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Preoperative high-dose Steroids in Total Knee and Hip Arthroplasty - Protocols for three randomized controlled trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mean arterial pressure during targeted temperature management and renal function after out-of-hospital cardiac arrest

    Research output: Contribution to journalJournal articleResearchpeer-review

  • David J Gagnon
  • Niklas Nielsen
  • Gilles L Fraser
  • Richard R Riker
  • John Dziodzio
  • Kjetil Sunde
  • Jan Hovdenes
  • Pascal Stammet
  • Hans Friberg
  • Sten Rubertsson
  • Michael Wanscher
  • David B Seder
View graph of relations

INTRODUCTION: Prophylactic antibiotics (PRO) reduce the incidence of early-onset pneumonia in comatose patients with structural brain injury, but have not been examined in cardiac arrest survivors undergoing targeted temperature management (TTM). We investigated the effect of PRO on the development of pneumonia in that population.

METHODS: We conducted a retrospective cohort study comparing patients treated with PRO to those not receiving PRO (no-PRO) using Northern Hypothermia Network registry data. Cardiac arrest survivors ≥ 18 years of age with a GCS<8 at hospital admission and treated with TTM at 32-34 °C were enrolled in the registry. Differences were analyzed in univariate analyses and with logistic regression models to evaluate independent associations of clinical factors with incidence of pneumonia and good functional outcome.

RESULTS: 416 of 1240 patients (33.5%) received PRO. Groups were similar in age, gender, arrest location, initial rhythm, and time from collapse to return of spontaneous circulation. PRO patients had less pneumonia (12.6% vs. 54.9%, p < 0.001) and less sepsis (1.2 vs. 5.7%, p < 0.001) compared to no-PRO patients. ICU length of stay (98 vs. 100 h, p = 0.2) and incidence of a good functional outcome (41.1 vs. 36.6%, p = 0.19) were similar between groups. Backwards stepwise logistic regression demonstrated PRO were independently associated with a lower incidence of pneumonia (OR 0.09, 95% 0.06-0.14, p < 0.001) and a similar incidence of good functional outcome.

CONCLUSIONS: Prophylactic antibiotics were associated with a reduced incidence of pneumonia but a similar rate of good functional outcome.

Original languageEnglish
JournalResuscitation
Volume92
Pages (from-to)154-9
Number of pages6
ISSN0300-9572
DOIs
Publication statusPublished - Jul 2015

ID: 46170666