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Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

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Harvard

Ferland-McCollough, D, Fernandez-Twinn, DS, Cannell, IG, David, H, Warner, M, Vaag, AA, Bork-Jensen, J, Brøns, C, Gant, TW, Willis, AE, Siddle, K, Bushell, M & Ozanne, SE 2012, 'Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes' Cell Death and Differentiation, vol. 19, no. 6, pp. 1003-12. https://doi.org/10.1038/cdd.2011.183

APA

Ferland-McCollough, D., Fernandez-Twinn, D. S., Cannell, I. G., David, H., Warner, M., Vaag, A. A., ... Ozanne, S. E. (2012). Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death and Differentiation, 19(6), 1003-12. https://doi.org/10.1038/cdd.2011.183

CBE

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE. 2012. Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death and Differentiation. 19(6):1003-12. https://doi.org/10.1038/cdd.2011.183

MLA

Vancouver

Author

Ferland-McCollough, D ; Fernandez-Twinn, Denise S ; Cannell, I G ; David, H ; Warner, M ; Vaag, A A ; Bork-Jensen, J ; Brøns, C ; Gant, T W ; Willis, A E ; Siddle, K ; Bushell, M ; Ozanne, Susan E. / Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. In: Cell Death and Differentiation. 2012 ; Vol. 19, No. 6. pp. 1003-12.

Bibtex

@article{29a6719baa274bd4bbfa9e5c058f0d4a,
title = "Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes",
abstract = "Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.",
keywords = "3' Untranslated Regions, Adipose Tissue, Adult, Animals, Animals, Newborn, Base Sequence, Cell Differentiation, Diabetes Mellitus, Type 2, Diet, Disease Models, Animal, Down-Regulation, Female, Growth Differentiation Factor 3, HEK293 Cells, Humans, Lipid Metabolism, Male, MicroRNAs, RNA Interference, RNA, Small Interfering, Rats, Rats, Wistar, Journal Article, Research Support, Non-U.S. Gov't",
author = "D Ferland-McCollough and Fernandez-Twinn, {Denise S} and Cannell, {I G} and H David and M Warner and Vaag, {A A} and J Bork-Jensen and C Br{\o}ns and Gant, {T W} and Willis, {A E} and K Siddle and M Bushell and Ozanne, {Susan E}",
year = "2012",
month = "6",
doi = "10.1038/cdd.2011.183",
language = "English",
volume = "19",
pages = "1003--12",
journal = "Cell Death and Differentiation",
issn = "1350-9047",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

AU - Ferland-McCollough, D

AU - Fernandez-Twinn, Denise S

AU - Cannell, I G

AU - David, H

AU - Warner, M

AU - Vaag, A A

AU - Bork-Jensen, J

AU - Brøns, C

AU - Gant, T W

AU - Willis, A E

AU - Siddle, K

AU - Bushell, M

AU - Ozanne, Susan E

PY - 2012/6

Y1 - 2012/6

N2 - Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.

AB - Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.

KW - 3' Untranslated Regions

KW - Adipose Tissue

KW - Adult

KW - Animals

KW - Animals, Newborn

KW - Base Sequence

KW - Cell Differentiation

KW - Diabetes Mellitus, Type 2

KW - Diet

KW - Disease Models, Animal

KW - Down-Regulation

KW - Female

KW - Growth Differentiation Factor 3

KW - HEK293 Cells

KW - Humans

KW - Lipid Metabolism

KW - Male

KW - MicroRNAs

KW - RNA Interference

KW - RNA, Small Interfering

KW - Rats

KW - Rats, Wistar

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/cdd.2011.183

DO - 10.1038/cdd.2011.183

M3 - Journal article

VL - 19

SP - 1003

EP - 1012

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

SN - 1350-9047

IS - 6

ER -

ID: 51555070