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Rigshospitalet - a part of Copenhagen University Hospital

Prognostic molecular markers in pediatric liver disease - Are there any?

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Pediatric liver disease (PLD) is a major cause of severe morbidity and prolonged hospitalizations in children. Stratifying patients in terms of prognosis remains challenging. The limited knowledge about molecular mechanisms causing and accompanying PLD remains the main obstacle in a search for reliable prognostic biomarkers. A systematic search of MEDLINE via PubMed and Embase via OVID was conducted on studies published between August 2007 and August 2017. Molecular markers with a prognostic potential in terms of survival, need for liver transplantation or disease progression/regression were selected. In general, identified studies were single center smaller case-control studies or case series with a low level of evidence and a high risk of bias. Only 23 studies comprising 898 patients could be included, mostly focusing on biliary atresia, non-alcoholic fatty liver disease, viral hepatitis, and LT; and markers related to morphogenesis and fibrosis. Furthermore, molecular markers in metabolic pathways and inflammation shown to be relevant, however requiring further validation. Hence, further biological and clinical studies are needed to gain greater molecular insight into PLD.

Original languageEnglish
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number3
Pages (from-to)577-586
Number of pages10
Publication statusPublished - 1 Mar 2019

    Research areas

  • Age of Onset, Biomarkers/analysis, Case-Control Studies, Child, Disease Progression, Humans, Liver Diseases/diagnosis, Non-alcoholic Fatty Liver Disease/diagnosis, Prognosis

ID: 56502503