Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Prognostic factors of 90-day mortality in patients hospitalised with COVID-19

Research output: Contribution to journalJournal articleResearchpeer-review

  1. SARS-CoV-2 in saliva, oropharyngeal and nasopharyngeal specimens

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characteristics of Danish children registered with and pharmacologically treated for hypertension

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Multivitamin intake does not affect the risk of preterm and very preterm birth

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Time from injury to arrival at the trauma centre in patients undergoing interhospital transfer

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Akral iskæmi med multiple mikrotromber og truende gangræn ved COVID-19-infektion

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Christian Brieghel
  • Peter Ellekvist
  • Marie Louise Lund
  • Christian Søborg
  • Emil Schwartz Walsted
  • Jonas Juhl Thomsen
  • Tor Biering-Sørensen
  • Thomas Mohr
  • Filip Krag Knop
  • Pernille Ravn
View graph of relations

INTRODUCTION: Mortality due to COVID-19 is higher among elderly patients with comorbidities. Even so, prognostication in COVID-19 remains limited.

METHODS: We assessed 90-day mortality stratified by comorbidities, routine biochemical markers and oxygen need in a consecutive single-centre cohort from 2 March to 2 June 2020.

RESULTS: We included 263 hospitalised patients with laboratory-confirmed COVID-19. On admission, fitness for intensive care was determined in 254 patients including 98 (39%) with a do-not-resuscitate order. Ninety-day overall mortality was 29%, whereas intensive care unit (ICU) mortality was 35% (14/40). Alcohol abuse, liver disease and elevated urea were strongly associated with mortality in univariable analyses. In a mutually adjusted multivariable analysis, we found an independent incremental increase in 90-day mortality with each increasing age by decade (hazard ratio (HR) = 1.5; 95% confidence interval (CI): 1.2-1.9), Charlson Comorbidity Index (CCI) score (HR = 1.2; 95% CI: 1.0-1.4), number of abnormal blood tests (HR = 1.2; 95% CI: 1.1-1.3) and l/min. of supplemental oxygen (HR = 1.1; 95% CI: 1.1-1.2).

CONCLUSIONS: The overall mortality was similar to that of other hospitalised patients, whereas the ICU mortality was lower than expected. On admission, each additional age by decade, CCI score, number of abnormal blood tests and magnitude of supplemental oxygen were independently associated with increased mortality.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

Original languageEnglish
JournalDanish Medical Journal
Volume68
Issue number3
ISSN1603-9629
Publication statusPublished - 22 Feb 2021

    Research areas

  • Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, COVID-19/diagnosis, Child, Cohort Studies, Critical Care, Denmark, Female, Hospital Mortality, Hospitalization, Humans, Male, Middle Aged, Survival Rate, Young Adult

ID: 65066390