Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Primary transoral robotic surgery with concurrent neck dissection for early stage oropharyngeal squamous cell carcinoma implemented at a Danish head and neck cancer center: a phase II trial on feasibility and tumour margin status

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Developing a national e-learning course in otorhinolaryngology: the Danish experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ultra-high-fidelity virtual reality mastoidectomy simulation training: a randomized, controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. FDG-PET/CT in the surveillance of head and neck cancer following radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Value of pre- and intraoperative diagnostic methods in suspected glottic neoplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development of depression in patients with oral cavity cancer: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Chronic rhinosinusitis in COPD: A prevalent but unrecognized comorbidity impacting health related quality of life

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

There is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the western world due to human papillomavirus (HPV). According to the Danish Head and Neck Cancer Group guidelines, the current recommended treatment of patients with OPSCC in Denmark is primary radiation therapy (RT) with or without concomitant chemotherapy. This is the first study in Scandinavia from a head and neck cancer centre that aims to demonstrate the feasibility of performing primary transoral robotic surgery (TORS) and concurrent neck dissection for patients with early stage OPSCC. Between September 2014 and January 2016, 30 consecutive patients with clinical T1-T2, N0-N1 OPSCC underwent primary TORS and concurrent neck dissection. The patients were offered postoperative adjuvant therapy according to pathological risk parameters: pT >2, T-site margin <2 mm, pN >1 or extracapsular extension (ECE). Concomitant chemotherapy was offered to patients with the presence of ECE or involved margins. Twenty-nine patients had negative margins on T-site after primary resection. Only one patient had a close margin of 1 mm. Unilateral neck dissection was performed in 21 patients while nine patients underwent bilateral neck dissection. Due to an upstaging following surgery, 13 patients were referred to adjuvant therapy. Four of these patients received RT and two patients received concomitant chemo-radiation (CCR) therapy. Seven patients declined the recommended adjuvant therapy one of whom later developed an N-site recurrence and received salvage surgery with postoperative RT. In summary, 43% of the patients were referred to adjuvant therapy following primary surgery which was mainly due to N-site stage migration and ECE. Primary TORS and concurrent neck dissection is a safe and feasible procedure that may be an alternative to primary RT and CCR in a selected group of patients with early stage OPSCC.

Original languageEnglish
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Volume274
Issue number5
Pages (from-to)2229-37
ISSN0003-9195
DOIs
Publication statusPublished - 3 Jan 2017

ID: 49633377