Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Prevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Biofilm formation - what we can learn from recent developments

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association of the blood eosinophil count with end-organ symptoms

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hydrochloric acid prolongs the lifetime of central venous catheters in haematologic patients with bacteraemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  • C L Andersen
  • D Tesfa
  • V D Siersma
  • H Sandholdt
  • H Hasselbalch
  • O W Bjerrum
  • P Felding
  • B Lind
  • Niels de F Olivarius
  • J Palmblad
View graph of relations

BACKGROUND: Neutropenia, defined as an absolute blood neutrophil count (ANC) <1.5 G L(-1) , may accompany a variety of diseases. However, the clinical significance of neutropenia detected in a routine complete blood cell count is poorly understood.

METHODS: Using a primary care resource, comprising more than 370 000 individuals, we assessed the association with a number of previously recognized conditions as well as all-cause mortality in the 4 years following the identification of neutropenia. By matching laboratory data with Danish nationwide health registers, risk estimates were assessed.

RESULTS: Neutropenia was observed in approximately 1% of all individuals and was associated dose dependently with viral infections, haematological malignancies (but not autoimmune disorders or solid cancers) and mortality. Neutropenia was particularly associated with HIV, acute leukaemias and myelodysplastic syndromes. Odds ratios [95% confidence interval (CI)] for viral infections were 2.32 (1.84-2.91), 2.80 (2.20-3.57) and 4.77 (3.22-7.07) for subnormal (≥1.5-1.8 G L(-1) ), mild (≥1.0-1.5 G L(-1) ) and moderate-severe (≥0.0-1.0 G L(-1) ) neutropenic individuals, respectively (all P < 0.001). Likewise, odds ratios (95% CI) for haematological malignancies were 3.23 (2.35-4.45), 8.69 (6.58-11.47) and 46.03 (33.98-62.35 ), for the same neutropenia levels, respectively (all P < 0.001). Thus, the lower the ANC, the greater the likelihood of these diseases. The relative risk estimates observed for severe neutropenia corresponded to absolute risks of haematological malignancies and mortality from any cause of 40% and >50%, respectively.

CONCLUSIONS: Neutropenia is an ominous sign necessitating careful follow-up. The risk estimates presented here support focusing attention to viral diseases and haematological malignancies when neutropenia is observed.

Original languageEnglish
JournalJournal of Internal Medicine
Volume279
Issue number6
Pages (from-to)566-75
Number of pages10
ISSN0954-6820
DOIs
Publication statusPublished - Jun 2016

    Research areas

  • Journal Article

ID: 49463793