Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Pregnancy loss and risk of multiple sclerosis and autoimmune neurological disorder: A nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. "We can't do without it": Parent and call-handler experiences of video triage of children at a medical helpline

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The impact of rifaximin on inflammation and metabolism in alcoholic hepatitis: A randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. SARS-CoV-2 seroprevalence among patients with severe mental illness: A cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Feelings of guilt and loss of control dominate in stress and depression inventories from women with recurrent pregnancy loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Environmental factors in declining human fertility

    Research output: Contribution to journalReviewResearchpeer-review

  3. Cyproterone acetate and risk of meningioma: a nationwide cohort study

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

BACKGROUND: The loss of one or more pregnancies before viability (i.e. pregnancy loss or miscarriage), has been linked to an increased risk of diseases later in life such as myocardial infarction and stroke. Recurrent pregnancy loss (i.e. three consecutive pregnancy losses) and multiple sclerosis have both been linked to immunological traits, which could predispose to both occurrences. The objective of the current study was to investigate if pregnancy loss is associated with later autoimmune neurological disease.

METHODS: This register-based cohort study, included the Danish female population age 12 or older between 1977-2017. Women were grouped hierarchically: 0, 1, 2, ≥3 pregnancy losses, primary recurrent pregnancy loss (i.e. not preceded by a delivery), and secondary recurrent pregnancy loss (i.e. preceded by a delivery). The main outcome was multiple sclerosis and additional outcomes were amyotrophic lateral sclerosis, Guillain-Barré syndrome, and myasthenia gravis. Bayesian Poisson regression estimated incidence rate ratios [IRR] and 95% credible intervals [CI] adjusted for year, age, live births, family history of an outcome, and education.

RESULTS: After 40,380,194 years of follow-up, multiple sclerosis was diagnosed among 7,667 out of 1,513,544 included women (0.5%), median age at diagnosis 34.2 years (IQR 27.4-41.4 years), and median age at symptom onset 31.2 years (IQR 24.8-38.2). The adjusted IRR of multiple sclerosis after 1 pregnancy loss was: 1.03 (95% CI 0.95-1.11), 2 losses: 1.02 (95% CI 0.86-1.20), ≥3 non-consecutive losses: 0.81 (95% CI 0.51-1.24), primary recurrent pregnancy loss: 1.18 (95% CI 0.84-1.60), secondary recurrent pregnancy loss: 1.16 (95% CI 0.81-1.63), as compared to women with no pregnancy losses. Seven sensitivity analyses and analyses for additional outcomes did not show significantly elevated adjusted risk estimates.

CONCLUSIONS: In this nationwide study, pregnancy loss was not significantly associated with autoimmune neurological disorder.

Original languageEnglish
Article numbere0266203
JournalPLoS One
Volume17
Issue number3
ISSN1932-6203
DOIs
Publication statusPublished - 31 Mar 2022

ID: 76290609