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Rigshospitalet - a part of Copenhagen University Hospital
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Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure

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  1. Cardiac natriuretic peptides

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  2. Catheter ablation and mortality, stroke and heart failure readmission with atrial fibrillation

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  3. Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes

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Our aim was to assess the prognostic impact of a high-sensitivity cardiac troponin T (hs-cTnT) assay in an outpatient population with chronic systolic left ventricular heart failure (HF). Four hundred sixteen patients with chronic HF and left ventricular ejection fraction ≤ 45% were enrolled in a prospective cohort study. In addition to hs-cTnT, plasma amino-terminal pro-B-type natriuretic peptide was measured at baseline. Mean age was 71 years, 29% were women, 62% had coronary artery disease (CAD), mean left ventricular ejection fraction was 31%, and 57% had abnormal level of hs-cTnT. During 4.4 years of follow-up, 211 (51%) patients died. In multivariate Cox regression models, hs-cTnT was categorized as quartiles or dichotomized by the 99th percentile of a healthy population. Adjusted hazard ratios for all-cause mortality for quartiles 2 to 4, with quartile 1 as reference, were 1.4 (95% confidence interval 0.9 to 2.4, p = 0.16) for quartile 2, 1.7 (0.9 to 2.5, p = 0.12) for quartile 3, and 2.6 (1.6 to 4.4, p
Original languageEnglish
JournalAmerican Journal of Cardiology
Volume110
Issue number4
Pages (from-to)552-7
Number of pages6
ISSN0002-9149
DOIs
Publication statusPublished - 2012

    Research areas

  • Aged, Aged, 80 and over, Chronic Disease, Cohort Studies, Coronary Artery Disease, Female, Follow-Up Studies, Heart Failure, Systolic, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Predictive Value of Tests, Prevalence, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Factors, Stroke Volume, Survival Rate, Troponin T, Ventricular Dysfunction, Left

ID: 36746207