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Rigshospitalet - a part of Copenhagen University Hospital
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Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36

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  2. Blocking of efflux transporters in rats improves translational validation of brain radioligands

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  3. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women

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[11C]Cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2A receptors (5-HT2A) with positron emission tomography (PET). This may be used to quantify the high-affinity state of 5-HT2A receptors and may have the potential to quantify changes in cerebral 5-HT levels in vivo. We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology.
Original languageEnglish
JournalMolecular Imaging and Biology
Volume15
Issue number4
Pages (from-to)376-83
Number of pages8
ISSN1536-1632
DOIs
Publication statusPublished - Aug 2013

ID: 42576417