Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Postoperative epilepsy and survival in glioma patients: a nationwide population-based cohort study from 2009 to 2018

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Molecular profiling of short-term and long-term surviving patients identifies CD34 mRNA level as prognostic for glioblastoma survival

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pooled analysis of recent studies of magnetic fields and childhood leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pregnancy outcomes in women with neurofibromatosis 1: a Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prediagnosis epilepsy and survival in patients with glioma: a nationwide population-based cohort study from 2009 to 2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mirketa Marku
  • Birthe Krogh Rasmussen
  • Federica Belmonte
  • Elisabeth Anne Wreford Andersen
  • Christoffer Johansen
  • Pernille Envold Bidstrup
View graph of relations

PURPOSE: Postoperative epilepsy is common in glioma patients and has been suggested to indicate disease progression, yet knowledge of its role as a prognostic factor is limited. This study investigates the association between postoperative epilepsy and survival amongst patients with gliomas.

METHODS: We included 3763 patients with histopathologically diagnosed grade II, III, and IV gliomas from 2009 to 2018 according to the Danish Neuro-Oncology Registry. Information on epilepsy diagnosis was redeemed from the Danish National Patient Registry, the National Prescription Registry and the Danish Neuro-Oncology Registry. We used Cox proportional hazards models with 95% confidence intervals (CIs) to examine hazard ratios (HRs) for the association between postoperative epilepsy and risk of death. We examined the role of the timing of epilepsy in three different samples: Firstly, in all glioma patients with postoperative epilepsy; secondly, in patients with postoperative de novo epilepsy; thirdly, exclusively in a homogeneous sub-group of grade IV patients with postoperative de novo epilepsy.

RESULTS: Glioma patients with postoperative epilepsy had an increased risk of death, regardless of prior epilepsy status (HR = 4.03; CI 2.69-6.03). A similar increase in the risk of death was also seen in patients with postoperative de novo epilepsy (HR = 2.08; CI 1.26-3.44) and in the sub-group of grade IV patients with postoperative de novo epilepsy (HR = 1.83; CI 1.05-3.21).

CONCLUSIONS: Postoperative epilepsy may negatively impact survival after glioma diagnosis, regardless of preoperative epilepsy status. Postoperative epilepsy may be an expression of a more invasive growth pattern of the gliomas following primary tumor treatment.

Original languageEnglish
JournalJournal of Neuro-Oncology
Volume157
Issue number1
Pages (from-to)71-80
Number of pages10
ISSN0167-594X
DOIs
Publication statusPublished - Mar 2022

Bibliographical note

© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

    Research areas

  • Epilepsy, Glioma, Grade, Postoperative, Survival

ID: 73459284