Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Plasma YKL-40 during pregnancy and gestational diabetes mellitus

Research output: Contribution to journalJournal articleResearchpeer-review

  1. HLA-DRB1 polymorphism in recurrent pregnancy loss: New evidence for an association to HLA-DRB1*07

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Soluble HLA-G and TGF-β in couples attending assisted reproduction - A possible role of TGF-β isoforms in semen?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Physical exercise for people with cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Comparative Effectiveness of Low-Volume Time-Efficient Resistance Training Versus Endurance Training in Patients With Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Physical exercise for people with cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impaired follistatin secretion in cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Gestational diabetes mellitus (GDM) is characterised by hyperglycaemia during pregnancy. The clinical circumstances involved in the development of GDM leaves the patient at a high risk of the subsequent development of type 2 diabetes. Plasma levels of the inflammation marker YKL-40 are elevated in type 2 diabetes and correlate with fasting plasma glucose levels and insulin resistance in patients with type 2 diabetes. With the present study we aimed to determine if pregnancy (and associated insulin resistance) with or without GDM affects plasma YKL-40 levels. Plasma from women diagnosed with GDM and healthy normal glucose-tolerant pregnant women (non-GDM) was obtained at the third trimester of pregnancy and again 3-4 months following delivery, and levels of YKL-40 and interleukin 6 (IL-6; known to regulate YKL-40) were measured. Plasma YKL-40 levels were similarly low during pregnancy in both groups and increased significantly after delivery, but remained lower in the GDM group compared with the non-GDM group postpartum. In contrast, plasma IL-6 levels were not affected by pregnancy or diagnosis of GDM, Nevertheless, YKL-40 levels were associated with IL-6 levels in the non-GDM group (but not in the GDM group). Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women.

Original languageEnglish
JournalJournal of Reproductive Immunology
Volume112
Pages (from-to)68-72
Number of pages5
ISSN0165-0378
DOIs
Publication statusPublished - Nov 2015

ID: 46216349