Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The European Heart Journal: leading the fight to reduce the global burden of cardiovascular disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Sudden cardiac death among persons with diabetes aged 1-49 years: a 10-year nationwide study of 14 294 deaths in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sudden death in heart failure: do we understand what we observe?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High low-density lipoprotein levels and high risk of aortic stenosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Apolipoprotein M and risk of type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The European Heart Journal: leading the fight to reduce the global burden of cardiovascular disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Autosomal recessive hypercholesterolemia in a kindred of Syrian ancestry

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Genetic variants in SUSD2 are associated with the risk of ischemic heart disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIMS: To determine whether plasma apoE levels and APOE genotype are associated with all-cause and cause-specific mortality.

METHODS AND RESULTS: Using a prospective cohort design with 105 949 white individuals from the general population, we tested the association between plasma apoE at study enrolment and death during follow-up, and whether this was independent of APOE genotype. We confirmed the well-known association between APOE genotypes and mortality. For all-cause, cardiovascular, and cancer mortality, high levels of apoE were associated with increased risk, while for dementia-associated mortality low levels were associated with increased risk. For the highest vs. the fifth septile of plasma apoE, hazard ratios (HRs) were 1.20 (95% confidence interval 1.12-1.28) for all-cause mortality, 1.28 (1.13-1.44) for cardiovascular mortality, and 1.18 (1.05-1.32) for cancer mortality. Conversely, for the lowest vs. the fifth septile the HR was 1.44 (1.01-2.05) for dementia-associated mortality. Results were similar in analyses restricted to APOE ɛ33 carriers. Examining genetically determined plasma apoE, a 1 mg/dL increase conferred risk ratios of 0.97 (0.92-1.03) for cardiovascular mortality and 1.01 (0.95-1.06) for cancer mortality, while a 1 mg/dL decrease conferred a risk ratio of 1.70 (1.36-2.12) for dementia-associated mortality.

CONCLUSION: High plasma levels of apoE were associated with increased all-cause, cardiovascular, and cancer mortality, however of a non-causal nature, while low levels were causally associated with increased dementia-associated mortality.

Original languageEnglish
JournalEuropean Heart Journal
Volume40
Issue number33
Pages (from-to)2813-2824
Number of pages12
ISSN0195-668X
DOIs
Publication statusPublished - 1 Sep 2019

ID: 58188910