Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Physical exercise may increase plasma concentration of high-density lipoprotein-cholesterol in patients with alzheimer's disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Untreated Patients Dying With AIDS Have Loss of Neocortical Neurons and Glia Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Research output: Contribution to journalLetterResearchpeer-review

  2. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hospital readmissions following infections in dementia: a nationwide and registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hypophosphataemia is common in patients with aneurysmal subarachnoid haemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Lifestyle factors have been shown to increase the risk of developing Alzheimer's disease (AD) later in life. Specifically, an unfavorable cholesterol profile, and insulin resistance are associated with increased risk of developing AD. One way to non-pharmacologically affect the levels of plasma lipids is by exercise, which has been shown to be beneficial in cognitively healthy individuals. In this randomized controlled trial y, we therefore aimed to clarify the effect of physical exercise on the lipid profile, insulin and glucose in patients with AD. In addition, we investigated the effect of apolipoproteinE genotype on total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG) in plasma from patients with AD. Plasma samples from 172 patients who underwent 16 weeks of moderate-to-high intensity exercise (n = 90) or treatment as usual (n = 82) were analyzed change from baseline for the levels of total cholesterol, LDL-C, HDL-C, TG, glucose, and insulin. In addition, we analyzed those from the exercise group who adhered to the protocol with an attendance of 2/3 or more of the exercise session and who followed the protocol of an intensity of 70% of the maximum heart rate. We found a significant increase in plasma HDL-C levels between the "high exercise sub-group" compared to control group. After intervention HDL-C was increased by 4.3% in the high-exercise group, and decreased by 0.7% in the control group, after adjustment for statin use. In conclusion, short term physical activity may be beneficial on the cholesterol profile in patients with AD.

Original languageEnglish
Article number532
JournalFrontiers in Neuroscience
Volume14
ISSN1662-4548
DOIs
Publication statusPublished - 2020

    Research areas

  • Alzheimer’s disease, cholesterol, exercise, fitness, HDL-C, lipid profile

ID: 60274844