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Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system

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  1. Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries

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  2. Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

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  1. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds

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  2. Familial analysis reveals rare risk variants for migraine in regulatory regions

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  3. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

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Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation of the cranial arteries may also play a role in increasing nociception. Prostaglandin I(2) (PGI(2)) is capable of inducing a headache in healthy volunteers, a response that is likely to be mediated by the prostaglandin I(2) receptor (IP). This study investigates the functional and molecular characteristics of the IP receptor in the rat craniovascular system. In the closed cranial window model, iloprost, an IP receptor agonist, dilated the rat middle meningeal artery (MMA) (E(max)=170%±16%; pED(50)=6.5±0.2) but not the rat cerebral artery (CA) in vivo. The specific antagonist of the IP receptor, CAY10441, significantly blocked the iloprost-induced response dose-dependently, with the highest dose attenuating iloprost (1μgkg(-1)) induced dilatations by 70% (p
Original languageEnglish
JournalVascular Pharmacology
Volume55
Issue number1-3
Pages (from-to)50-8
Number of pages9
ISSN1537-1891
DOIs
Publication statusPublished - Jul 2011

    Research areas

  • Animals, Benzyl Compounds, Cerebral Arteries, Epoprostenol, Iloprost, Imidazoles, Male, Meningeal Arteries, Muscle, Smooth, Vascular, Nociception, Rats, Rats, Sprague-Dawley, Receptors, Epoprostenol, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Vasodilation, Vasodilator Agents

ID: 34670673