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Rigshospitalet - a part of Copenhagen University Hospital
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Pattern of and survival following loco-regional and distant recurrence in patients with HPV+ and HPV- oropharyngeal squamous cell carcinoma: A population-based study

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  1. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

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  2. Comorbidity in HPV+ and HPV- oropharyngeal cancer patients: A population-based, case-control study

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  3. The effects of checkpoint inhibition on head and neck squamous cell carcinoma: A systematic review

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  4. MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

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  1. Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas

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  2. Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study

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  3. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

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  4. Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

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  5. Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review

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OBJECTIVES: The incidence of human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Currently, data is sparse on the pattern and timing of recurrence. This long-term study concerning both HPV- and p16-status aimed to report predictive factors, pattern, timing of loco-regional recurrence (LRR) and distant recurrence (DR), and survival following recurrence in patients diagnosed with OPSCC.

MATERIAL AND METHODS: We included patients diagnosed with OPSCC from 2000 to 2014 in Eastern Denmark, who were treated with curative intent. Tumors were defined as HPV-positive when they were both HPV-DNA and p16-positive. Time-to-failure and -death were estimated by the Kaplan-Meier method. Cox proportional hazards models were used to evaluate predictors of failure.

RESULTS: The cohort consisted of 1244 consecutive patients with OPSCC of which 288 patients (23%) experienced recurrence. Of these patients, the majority (n = 197/1244; 16%) experienced LRR and the remaining (n = 91/1244; 7%) DR. Significantly more HPV-negative patients experienced recurrence (n = 170/486; 35%) compared to HPV-positive patient (n = 112/726; 15%). DR occurred for both groups predominantly to the lung (n = 63/91; 69.2%) followed by the liver and bone. Factors influencing risk of LRR included gender, T-classification, and HPV-status. The same variables influenced risk of DR in addition to the UICC-8 classification, N-classification, pack years of smoking, and performance status. HPV-status was the strongest risk factor for LRR and DR.

CONCLUSION: LRR and DR occur significantly less often in HPV-positive patients compared with HPV-negative patients. HPV-status is an independent and strong predictor of recurrence. DR most commonly occurs to the lungs, irrespective of HPV-status.

Original languageEnglish
JournalOral Oncology
Volume83
Pages (from-to)127-133
Number of pages7
ISSN1368-8375
DOIs
Publication statusPublished - Aug 2018

ID: 55838924