Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Patient characteristics of olfactory neuroblastoma: experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

    Research output: Contribution to journalReviewResearchpeer-review

  2. APMIS pandemic editorial

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Pandemics: past, present, future: That is like choosing between cholera and plague

    Research output: Contribution to journalReviewResearchpeer-review

  1. Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

    Research output: Contribution to journalReviewResearchpeer-review

  4. Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume126
Issue number8
Pages (from-to)663-666
Number of pages4
ISSN0903-4641
DOIs
Publication statusPublished - Aug 2018

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Denmark, Esthesioneuroblastoma, Olfactory/mortality, Female, Gamma Rays/therapeutic use, Hospitals, University, Humans, Male, Middle Aged, Nasal Cavity/drug effects, Neoplasm Grading, Neoplasm Staging, Nose Neoplasms/mortality, Prognosis, Registries, Retrospective Studies, Survival Analysis

ID: 56645607