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Pathogenic CD8+ Epidermis-Resident Memory T Cells Displace Dendritic Epidermal T Cells in Allergic Dermatitis

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  • Anne-Sofie Ø Gadsbøll
  • Mia H Jee
  • Anders B Funch
  • Maria Alhede
  • Veronika Mraz
  • Julie F Weber
  • Lauren A Callender
  • Elizabeth C Carroll
  • Thomas Bjarnsholt
  • Anders Woetmann
  • Niels Ødum
  • Allan R Thomsen
  • Jeanne D Johansen
  • Sian M Henson
  • Carsten Geisler
  • Charlotte M Bonefeld
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The skin is our interface with the outside world, and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T-cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen DNFB results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knockout mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells, which again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC.

Original languageEnglish
JournalJournal of Investigative Dermatology
Volume140
Issue number4
Pages (from-to)806-815.e5
ISSN0022-202X
DOIs
Publication statusPublished - 10 Apr 2020

    Research areas

  • Animals, CD8-Positive T-Lymphocytes/immunology, Dendritic Cells/immunology, Dermatitis, Allergic Contact/immunology, Disease Models, Animal, Epidermis/pathology, Immunologic Memory, Mice, Mice, Knockout

ID: 58994404