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Rigshospitalet - a part of Copenhagen University Hospital
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Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression

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  3. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

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  4. Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding

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  1. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

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  2. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

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  3. Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

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Perinatal depression (PND) affects 15% of women. During the perinatal period both stress- and gonadal hormones fluctuate widely. Putatively, these fluctuations are involved in PND disease mechanisms. The serotonin system is sensitive to such hormone fluctuations, and serotonin reuptake inhibitors (SSRIs) are used to treat PND, although treatment is suboptimal and it is not known at which peripartum time-point SSRI treatment may be most efficacious. In this study, we investigate the effect of the SSRI paroxetine (5mg/kgs.c.) on swim stress-induced corticosterone in a rat model of postpartum depression. In the rat model corticosterone (CORT; 40mg/kgs.c.) was administered in Sprague Dawley rats across postpartum day (PD)2 to PD14. Stress response was measured during the first exposure to the forced swim test (FST1), and depressive-like behavior was measured in both FST1 and FST2. We found that paroxetine completely blunted the swim stress-induced CORT response and increased depressive-like behavior in both FST1 and FST2. Our findings suggest that in the postpartum context, SSRIs compromise stress axis dynamics, which are needed for a healthy stress response. This is likely unfavorable for reversing depressive-like behavior and may provide a rationale for augmentation strategies beyond SSRIs alone to optimize the clinical management of PND.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume89
Pages (from-to)223-228
Number of pages6
ISSN0306-4530
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • Journal Article

ID: 53655834