Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Ovarian reserve markers in women using various hormonal contraceptives

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. SARS-CoV-2 in first trimester pregnancy: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pregnancy outcomes following oocyte donation

    Research output: Contribution to journalReviewResearchpeer-review

  4. Fertilitetsrådgivning af unge kvinder efter kræft

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Objectives: The aim of the study was to assess whether the ovarian reserve markers anti-Müllerian hormone (AMH) and antral follicle count (AFC) were lower among women using the progestin-only pill (POP) or levonorgestrel-releasing intrauterine system (LNG-IUS) and similar to the decrease observed in combined oral contraceptive (COC) pill users.Methods: This retrospective study comprised 565 hormonal contraceptive users (COC, POP, LNG-IUS or contraceptive vaginal ring) and 983 non-hormonal contraceptive users, who were seen in two Danish fertility assessment and counselling clinics between 2015 and 2019. Adjusted multiple regression analysis was used to examine the differences in AMH and AFC between hormonal and non-hormonal contraceptive users.Results: Compared with non-hormonal contraceptive users, AMH was 31.1% lower among COC users [95% confidence interval (CI) -39.6%, -25.9%; p < 0.001], 35.6% lower among POP users (95% CI -49.0%, -18.6%; p < 0.001) and 17.1% lower among LNG-IUS users (95% CI -31.4%, 0.002%; p = 0.052); no significant differences were seen among vaginal ring users. Compared with non-hormonal contraceptive users, AFC was 31.3% lower among COC users (95% CI -35.0%, -25.3%; p < 0.001) and 29.7% lower among POP users (-39.1%, -17.9%; p < 0.001); no significant differences were seen among LNG-IUS or vaginal ring users. Ovarian volume was more than 50% reduced among COC and vaginal ring users (p < 0.001) but was unchanged among POP and LNG-IUS users.Conclusion: Assessment of ovarian reserve markers among users of all types of hormonal contraception should be interpreted cautiously and the type of contraceptive method considered.

Original languageEnglish
JournalThe European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
Volume25
Issue number1
Pages (from-to)65-71
Number of pages7
ISSN1362-5187
DOIs
Publication statusPublished - Feb 2020

ID: 59199900