Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Total and central adiposity are associated with age at gonadarche and incidence of precocious gonadarche in boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Impact of Lean Body Mass and Insulin Sensitivity on the IGF-1-Bone Mass Axis in Adolescence: the EPICOM study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Male fertility before and after androgen abuse

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association between habitual sleep duration/quality and appetite markers in individuals with obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Chromogranin A in cardiovascular endocrinology

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cholecystokinin and the hormone concept

    Research output: Contribution to journalReviewpeer-review

  4. The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Effect of the natural sweetener xylitol on gut hormone secretion and gastric emptying in humans: a pilot dose-ranging study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Nikolaj Rittig
  • Mads Svart
  • Henrik Holm Thomsen
  • Esben Thyssen Vestergaard
  • Jens Frederik Rehfeld
  • Bolette Hartmann
  • Jens Juul Holst
  • Mogens Johannsen
  • Niels Møller
  • Niels Jessen
View graph of relations

BACKGROUND: D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also as an important signaling metabolite. Oral ketone supplements containing D/L-3-OHB are becoming a popular approach to achieve ketosis.

AIM: To explore the gut-derived effects of ketone supplements.

METHODS: Eight healthy lean male volunteers were investigated on 2 separate occasions:An acetaminophen test was performed to evaluate gastric emptying and blood samples were obtained consecutively throughout the study period.

RESULTS: We show that oral consumption of D/L-3-OHB stimulates cholecystokinin release (P = 0.02), elevates insulin (P = 0.03) and C-peptide (P < 0.001) concentrations, and slows gastric emptying (P = 0.01) compared with matched intravenous D/L-3-OHB administration. Measures of appetite and plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were unaffected by interventions.

CONCLUSION: Our findings show that D/L-3-OHB exert incretin effects and indicate luminal sensing in the gut endothelium. This adds to our understanding of ketones as signaling metabolites and displays the important difference between physiological ketosis and oral ketone supplements.

Original languageEnglish
Article numberdgaa483
JournalThe Journal of clinical endocrinology and metabolism
Volume105
Issue number10
Number of pages9
ISSN0021-972X
DOIs
Publication statusPublished - 1 Oct 2020

    Research areas

  • Cholecystokinin, Gastric emptying, Incretin, Insulin, Ketone, Nutrient sensing

ID: 60693788