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One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)

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  • Steve Cunningham
  • Catriona Graham
  • Morag MacLean
  • Paul Aurora
  • Michael Ashworth
  • Angelo Barbato
  • Alistair Calder
  • Julia Carlens
  • Annick Clement
  • Meike Hengst
  • Birgit Kammer
  • Nural Kiper
  • Katarzyna Krenke
  • Kai Kronfeld
  • Joanna Lange
  • Julia Ley-Zaporozhan
  • Andrew G Nicholson
  • Simone Reu
  • Traudl Wesselak
  • Martin Wetzke
  • Andrew Bush
  • Nicolaus Schwerk
  • Matthias Griese
  • ChILDEU study group
  • Frederik Buchvald (Member of study group)
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We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3-7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO2) median 92% (IQR 88-96). Death (n=20, 16%) was the most common in those <6 months of age with SpO2<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8-12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.

Original languageEnglish
JournalThorax
Volume75
Issue number2
Pages (from-to)172-175
Number of pages4
ISSN0040-6376
DOIs
Publication statusPublished - Feb 2020

Bibliographical note

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

    Research areas

  • Interstitial lung disease in Children, mortality, oxygen saturation, ventilation

ID: 59078269