Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

  1. DaPeCa-4: outcome in penile cancer patients with N3 disease due to extra nodal extension treated with surgery and chemo-irradiation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Educational level and first-time PSA testing in general practice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Left sided flank pain due to Bochdalek hernia with intrathoracic kidney

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Robotic versus laparoscopic urological surgery: incidence of reoperation and complications

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development and validation of a multiple-choice questionnaire-based theoretical test in direct ophthalmoscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reasons why not all Danish patients with muscle invasive bladder cancer receive neoadjuvant chemotherapy before radical cystectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Gathering Validity Evidence for Surgical Simulation: A Systematic Review

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Nessn H Azawi
  • Sara Haunstrup Næraa
  • Yousif Subhi
  • Juan Luis Vásquez
  • Thomas Norus
  • Claus Dahl
  • Peter Thind
  • Jørgen Bjerggaard Jensen
View graph of relations

Objective: To report the oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in a large study sample.Materials and methods: This was a nationwide multicenter registry-based cohort study of all patients with upper urinary tract urothelial neoplasia in Denmark found to be eligible for nephroureterectomy between April 2004 and April 2017 (N = 1384). Primary endpoints were intravesical recurrence-free survival and overall survival. Survival probabilities were estimated with Kaplan-Meier and the log-rank test to compare survival curves. Association with clinical outcomes was studied using univariate and multivariate Cox proportional hazards.Results: Intravesical recurrence-free survival was 72% [95% confidence interval (CI) 69-75%] at 5 years and 70% (95% CI 67-73%) at 10 years. Patients with muscle-invasive disease had a significantly lower rate of intravesical recurrence [hazard ratio (HR) = 0.46, p < 0.0001] and patients with high-grade tumors had a significantly higher rate of incident intravesical recurrence compared to low-grade tumors (HR = 1.65, p = 0.001). The overall survival was 76% (95% CI 74-79%) at 5 years and 64% (95% CI 60-70%) at 10 years. Patients with higher age (p = 0.008) and muscle-invasive disease (p < 0.0001) had worse overall survival. When comparing surgical approaches, laparoscopic nephroureterectomy versus open nephroureterectomy did not differ in intravesical recurrence-free survival but was associated with shorter postoperative hospital stay (p < 0.0001) and better overall survival (p = 0.02).Conclusions: We report the oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in a large sample and give insights into predictive factors with significant impact.

Original languageEnglish
JournalScandinavian Journal of Urology
Volume54
Issue number1
Pages (from-to)58-64
Number of pages7
ISSN2168-1805
DOIs
Publication statusPublished - Feb 2020

ID: 60879894