Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

OK-432 Treatment of Early Fetal Chylothorax: Pregnancy Outcome and Long-Term Follow-Up of 14 Cases

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Nørgaard, Lone Nikoline ; Nygaard, Ulrikka ; Damm, Julie Agner ; Esbjørn, Barbara Hoff ; Pedersen, Mette Marie Agner ; Rottbøll, Amanda ; Jørgensen, Connie ; Sundberg, Karin. / OK-432 Treatment of Early Fetal Chylothorax : Pregnancy Outcome and Long-Term Follow-Up of 14 Cases. In: Fetal Diagnosis and Therapy. 2019 ; Vol. 46, No. 2. pp. 81-87.

Bibtex

@article{3fa0cdb6f62c4c27aeb90dd4e29f8187,
title = "OK-432 Treatment of Early Fetal Chylothorax: Pregnancy Outcome and Long-Term Follow-Up of 14 Cases",
abstract = "BACKGROUND: The treatment options for fetal chylothorax include thoracocentesis, thoracoamniotic shunting, and pleurodesis using OK-432. Knowledge on the long-term outcomes after treatment with OK-432 is limited.OBJECTIVE: The aim of this study was to assess the long-term outcomes of children treated in utero with OK-432.METHODS: We performed follow-up on pregnancies and children treated in utero with OK-432 between 2003 and 2009 at Copenhagen University Hospital Rigshospitalet for pleural effusions at gestational age (GA) 16+0-21+6 weeks. Anamnestic information, physical examination, pulmonary function test, neuropediatric examination, and intelligence testing using the Wechsler Intelligence Scale were used for evaluation.RESULTS: Fourteen cases, all chylothorax, were treated with OK-432. None had preterm premature rupture of membranes (PPROM), and the median GA at delivery was 38+5 (24+4-41+5) weeks. Twelve children were eligible for follow-up. The median age at follow-up was 11.4 (7.8-13.8) years. Pulmonary function was normal in all children and the mean full-scale IQ did not differ from that of normal children. Four children had a diagnosed medical condition, attention deficit disorder, or genetic syndrome. The remaining children had normal follow-up.CONCLUSION: Children treated with OK-432 have comparable survival rates and long-term neurodevelopmental outcomes to those treated with thoracoamniotic shunts. There seems to be a lower risk of procedure-related PPROM.",
keywords = "Fetal chylothorax, Fetal hydrothorax, Fetal pleural effusions, Hydrops fetalis, OK-432",
author = "N{\o}rgaard, {Lone Nikoline} and Ulrikka Nygaard and Damm, {Julie Agner} and Esbj{\o}rn, {Barbara Hoff} and Pedersen, {Mette Marie Agner} and Amanda Rottb{\o}ll and Connie J{\o}rgensen and Karin Sundberg",
note = "{\circledC} 2018 S. Karger AG, Basel.",
year = "2019",
doi = "10.1159/000489775",
language = "English",
volume = "46",
pages = "81--87",
journal = "Fetal Diagnosis and Therapy",
issn = "1015-3837",
publisher = "S./Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - OK-432 Treatment of Early Fetal Chylothorax

T2 - Pregnancy Outcome and Long-Term Follow-Up of 14 Cases

AU - Nørgaard, Lone Nikoline

AU - Nygaard, Ulrikka

AU - Damm, Julie Agner

AU - Esbjørn, Barbara Hoff

AU - Pedersen, Mette Marie Agner

AU - Rottbøll, Amanda

AU - Jørgensen, Connie

AU - Sundberg, Karin

N1 - © 2018 S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: The treatment options for fetal chylothorax include thoracocentesis, thoracoamniotic shunting, and pleurodesis using OK-432. Knowledge on the long-term outcomes after treatment with OK-432 is limited.OBJECTIVE: The aim of this study was to assess the long-term outcomes of children treated in utero with OK-432.METHODS: We performed follow-up on pregnancies and children treated in utero with OK-432 between 2003 and 2009 at Copenhagen University Hospital Rigshospitalet for pleural effusions at gestational age (GA) 16+0-21+6 weeks. Anamnestic information, physical examination, pulmonary function test, neuropediatric examination, and intelligence testing using the Wechsler Intelligence Scale were used for evaluation.RESULTS: Fourteen cases, all chylothorax, were treated with OK-432. None had preterm premature rupture of membranes (PPROM), and the median GA at delivery was 38+5 (24+4-41+5) weeks. Twelve children were eligible for follow-up. The median age at follow-up was 11.4 (7.8-13.8) years. Pulmonary function was normal in all children and the mean full-scale IQ did not differ from that of normal children. Four children had a diagnosed medical condition, attention deficit disorder, or genetic syndrome. The remaining children had normal follow-up.CONCLUSION: Children treated with OK-432 have comparable survival rates and long-term neurodevelopmental outcomes to those treated with thoracoamniotic shunts. There seems to be a lower risk of procedure-related PPROM.

AB - BACKGROUND: The treatment options for fetal chylothorax include thoracocentesis, thoracoamniotic shunting, and pleurodesis using OK-432. Knowledge on the long-term outcomes after treatment with OK-432 is limited.OBJECTIVE: The aim of this study was to assess the long-term outcomes of children treated in utero with OK-432.METHODS: We performed follow-up on pregnancies and children treated in utero with OK-432 between 2003 and 2009 at Copenhagen University Hospital Rigshospitalet for pleural effusions at gestational age (GA) 16+0-21+6 weeks. Anamnestic information, physical examination, pulmonary function test, neuropediatric examination, and intelligence testing using the Wechsler Intelligence Scale were used for evaluation.RESULTS: Fourteen cases, all chylothorax, were treated with OK-432. None had preterm premature rupture of membranes (PPROM), and the median GA at delivery was 38+5 (24+4-41+5) weeks. Twelve children were eligible for follow-up. The median age at follow-up was 11.4 (7.8-13.8) years. Pulmonary function was normal in all children and the mean full-scale IQ did not differ from that of normal children. Four children had a diagnosed medical condition, attention deficit disorder, or genetic syndrome. The remaining children had normal follow-up.CONCLUSION: Children treated with OK-432 have comparable survival rates and long-term neurodevelopmental outcomes to those treated with thoracoamniotic shunts. There seems to be a lower risk of procedure-related PPROM.

KW - Fetal chylothorax

KW - Fetal hydrothorax

KW - Fetal pleural effusions

KW - Hydrops fetalis

KW - OK-432

U2 - 10.1159/000489775

DO - 10.1159/000489775

M3 - Journal article

VL - 46

SP - 81

EP - 87

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

SN - 1015-3837

IS - 2

ER -

ID: 56142492