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Rigshospitalet - a part of Copenhagen University Hospital
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Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

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  2. Kønsmodificerende kirurgi i Danmark

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  3. Uafklaret dyspnø.

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  4. Organisering af Perifer Nervekirurgi i Danmark

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  5. Mysteriet om guldtanden i lungen.

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  1. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

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  2. Challenges and opportunities for nephrology in Western Europe

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  3. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications

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Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

Translated title of the contributionNovel hormones related to the calcium and phosphate homeostasis in kidney disease
Original languageDanish
JournalUgeskrift for Laeger
Volume180
Issue number21
Pages (from-to)V05170353
ISSN0041-5782
Publication statusPublished - 21 May 2018

ID: 55810927