Harvard
Vogelezang, S, Bradfield, JP, Ahluwalia, TS, Curtin, JA, Lakka, TA, Grarup, N, Scholz, M, van der Most, PJ, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, IO, Vilor-Tejedor, N, Cousminer, DL, Standl, M, Wang, CA, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, JM, Zafarmand, MH, Heude, B, Farooqi, IS, Alyass, A, Beaumont, RN, Have, CT, Rzehak, P, Bilbao, JR, Schnurr, TM, Barroso, I, Bønnelykke, K, Chawes, B, Hansen, T
, Michaelsen, KF, Morgen, CS, Nielsen, TRH, Stokholm, J, Vinding, RK, Sørensen, TIA
, Holm, J-C, Bisgaard, H & Early Growth Genetics Consortium 2020, '
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits'
P L o S Genetics, vol. 16, no. 10, e1008718, pp. e1008718.
https://doi.org/10.1371/journal.pgen.1008718APA
Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Lakka, T. A., Grarup, N., ... Early Growth Genetics Consortium (2020).
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
P L o S Genetics,
16(10), e1008718. [e1008718].
https://doi.org/10.1371/journal.pgen.1008718CBE
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, Heiskala A, Horikoshi M, Fedko IO, Vilor-Tejedor N, Cousminer DL, Standl M, Wang CA, Viikari J, Geller F, Íñiguez C, Pitkänen N, Chesi A, Bacelis J, Yengo L, Torrent M, Ntalla I, Helgeland Ø, Selzam S, Vonk JM, Zafarmand MH, Heude B, Farooqi IS, Alyass A, Beaumont RN, Have CT, Rzehak P, Bilbao JR, Schnurr TM, Barroso I, Bønnelykke K, Chawes B, Hansen T
, Michaelsen KF, Morgen CS, Nielsen TRH, Stokholm J, Vinding RK, Sørensen TIA
, Holm J-C, Bisgaard H, Early Growth Genetics Consortium. 2020.
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
P L o S Genetics. 16(10):e1008718.
https://doi.org/10.1371/journal.pgen.1008718MLA
Vancouver
Author
Vogelezang, Suzanne ; Bradfield, Jonathan P ; Ahluwalia, Tarunveer S ; Curtin, John A ; Lakka, Timo A ; Grarup, Niels ; Scholz, Markus ; van der Most, Peter J ; Monnereau, Claire ; Stergiakouli, Evie ; Heiskala, Anni ; Horikoshi, Momoko ; Fedko, Iryna O ; Vilor-Tejedor, Natalia ; Cousminer, Diana L ; Standl, Marie ; Wang, Carol A ; Viikari, Jorma ; Geller, Frank ; Íñiguez, Carmen ; Pitkänen, Niina ; Chesi, Alessandra ; Bacelis, Jonas ; Yengo, Loic ; Torrent, Maties ; Ntalla, Ioanna ; Helgeland, Øyvind ; Selzam, Saskia ; Vonk, Judith M ; Zafarmand, Mohammed H ; Heude, Barbara ; Farooqi, Ismaa Sadaf ; Alyass, Akram ; Beaumont, Robin N ; Have, Christian T ; Rzehak, Peter ; Bilbao, Jose Ramon ; Schnurr, Theresia M ; Barroso, Inês ; Bønnelykke, Klaus ; Chawes, Bo ; Hansen, Torben
; Michaelsen, Kim F ; Morgen, Camilla S ; Nielsen, Tenna R H ; Stokholm, Jakob ; Vinding, Rebecca K ; Sørensen, Thorkild I A
; Holm, Jens-Christian ; Bisgaard, Hans ; Early Growth Genetics Consortium. /
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. In:
P L o S Genetics. 2020 ; Vol. 16, No. 10. pp. e1008718.
Bibtex
@article{acadf82d123f4b7daedfc978d2ae0aa3,
title = "Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits",
abstract = "The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R g ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.",
author = "Suzanne Vogelezang and Bradfield, {Jonathan P} and Ahluwalia, {Tarunveer S} and Curtin, {John A} and Lakka, {Timo A} and Niels Grarup and Markus Scholz and {van der Most}, {Peter J} and Claire Monnereau and Evie Stergiakouli and Anni Heiskala and Momoko Horikoshi and Fedko, {Iryna O} and Natalia Vilor-Tejedor and Cousminer, {Diana L} and Marie Standl and Wang, {Carol A} and Jorma Viikari and Frank Geller and Carmen {\'I}{\~n}iguez and Niina Pitk{\"a}nen and Alessandra Chesi and Jonas Bacelis and Loic Yengo and Maties Torrent and Ioanna Ntalla and {\O}yvind Helgeland and Saskia Selzam and Vonk, {Judith M} and Zafarmand, {Mohammed H} and Barbara Heude and Farooqi, {Ismaa Sadaf} and Akram Alyass and Beaumont, {Robin N} and Have, {Christian T} and Peter Rzehak and Bilbao, {Jose Ramon} and Schnurr, {Theresia M} and In{\^e}s Barroso and Klaus B{\o}nnelykke and Bo Chawes and Torben Hansen and Michaelsen, {Kim F} and Morgen, {Camilla S} and Nielsen, {Tenna R H} and Jakob Stokholm and Vinding, {Rebecca K} and S{\o}rensen, {Thorkild I A} and Jens-Christian Holm and Hans Bisgaard and {Early Growth Genetics Consortium}",
year = "2020",
month = "10",
day = "12",
doi = "10.1371/journal.pgen.1008718",
language = "English",
volume = "16",
pages = "e1008718",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "10",
}
RIS
TY - JOUR
T1 - Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
AU - Vogelezang, Suzanne
AU - Bradfield, Jonathan P
AU - Ahluwalia, Tarunveer S
AU - Curtin, John A
AU - Lakka, Timo A
AU - Grarup, Niels
AU - Scholz, Markus
AU - van der Most, Peter J
AU - Monnereau, Claire
AU - Stergiakouli, Evie
AU - Heiskala, Anni
AU - Horikoshi, Momoko
AU - Fedko, Iryna O
AU - Vilor-Tejedor, Natalia
AU - Cousminer, Diana L
AU - Standl, Marie
AU - Wang, Carol A
AU - Viikari, Jorma
AU - Geller, Frank
AU - Íñiguez, Carmen
AU - Pitkänen, Niina
AU - Chesi, Alessandra
AU - Bacelis, Jonas
AU - Yengo, Loic
AU - Torrent, Maties
AU - Ntalla, Ioanna
AU - Helgeland, Øyvind
AU - Selzam, Saskia
AU - Vonk, Judith M
AU - Zafarmand, Mohammed H
AU - Heude, Barbara
AU - Farooqi, Ismaa Sadaf
AU - Alyass, Akram
AU - Beaumont, Robin N
AU - Have, Christian T
AU - Rzehak, Peter
AU - Bilbao, Jose Ramon
AU - Schnurr, Theresia M
AU - Barroso, Inês
AU - Bønnelykke, Klaus
AU - Chawes, Bo
AU - Hansen, Torben
AU - Michaelsen, Kim F
AU - Morgen, Camilla S
AU - Nielsen, Tenna R H
AU - Stokholm, Jakob
AU - Vinding, Rebecca K
AU - Sørensen, Thorkild I A
AU - Holm, Jens-Christian
AU - Bisgaard, Hans
AU - Early Growth Genetics Consortium
PY - 2020/10/12
Y1 - 2020/10/12
N2 - The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R
g ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
AB - The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R
g ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
UR - http://www.scopus.com/inward/record.url?scp=85092931223&partnerID=8YFLogxK
U2 - 10.1371/journal.pgen.1008718
DO - 10.1371/journal.pgen.1008718
M3 - Journal article
VL - 16
SP - e1008718
JO - P L o S Genetics
JF - P L o S Genetics
SN - 1553-7390
IS - 10
M1 - e1008718
ER -
