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Nordic Haemophilia Council's practical guidelines on diagnosis and management of von Willebrand disease

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  • Riitta Lassila
  • Pål André Holme
  • Andrea Landorph
  • Pia Petrini
  • Páll T Onundarson
  • Andreas Hillarp
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Von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by spontaneous or tissue injury-related, mostly mucocutaneous, bleeding events. VWD affects both males and females and is caused by quantitative or qualitative deficiency of Von Willebrand factor. The diagnostic procedure is complicated because VWD is highly heterogeneous, and differential diagnosis from platelet disorders may be challenging. Moreover, these defects may even coexist, impacting the bleeding phenotype. Mild and moderate VWD can be difficult to distinguish from the normal population, and VWD subtyping may also be problematic. This article summarizes the guidelines of the Nordic Haemophilia Council (NHC), which are intended to serve as a practical tool and provide the standards for diagnosing and treating VWD patients. The complete Nordic Guidelines on VWD are available at the NHC Web site (
Original languageEnglish
JournalSeminars in Thrombosis and Hemostasis
Issue number5
Pages (from-to)495-502
Number of pages8
Publication statusPublished - 2011

ID: 33245125