Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Nocturnal Urinary Excretion of FSH and LH in Children and Adolescents With Normal and Early Puberty

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effect of dosage of 17ß-estradiol on uterine growth in Turner syndrome - a randomized controlled clinical pilot trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Gestational Diabetes Risk in Migrants. A Nationwide, Register-Based Study of all Births in Denmark 2004 to 2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The External Genitalia Score (EGS): A European multicenter validation study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Context: Clinical use of single serum gonadotropin measurements in children is limited by the pulsatile secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). However, first morning voided (FMV) urine may integrate the fluctuating gonadotropin serum levels.

Objective: We aimed to evaluate urinary and serum gonadotropin levels according to age, sex, and pubertal stage in healthy children and to assess the clinical use of FMV urinary gonadotropins in children with disordered puberty.

Design: Cross-sectional part of the COPENHAGEN Puberty Study and longitudinal study of patients.

Setting: Population-based and outpatient clinic.

Patients or Other Participants: Eight hundred forty-three healthy children from the COPENHAGEN Puberty Study and 25 girls evaluated for central precocious puberty (CPP).

Main Outcome Measures: Clinical pubertal staging, including serum and urinary gonadotropin levels.

Results: Urinary gonadotropins increased with advancing age and pubertal development and were detectable in FMV urine before physical signs of puberty. FMV urinary LH correlated strongly with basal (r = 0.871, P < 0.001) and gonadotropin-releasing hormone (GnRH)-stimulated serum LH (r = 0.82, P < 0.001). Urinary LH was superior to urinary FSH in differentiating the pubertal stage. Receiver operating curve analysis revealed that a cut-off standard deviation (SD) score of 2 for urinary LH (IU/L) gave a sensitivity of 75% and a specificity of 92% in predicting a positive GnRH stimulation test (LHmax > 5 IU/L). Urinary concentrations of LH decreased after 3 months of GnRH treatment to levels below +2 SDs.

Conclusions: Urinary gonadotropin levels increased before the onset of puberty and were elevated in girls with CPP. We suggest urinary LH as an alternative noninvasive method to improve diagnosing and therapeutic management of children with disordered puberty.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume102
Issue number10
Pages (from-to)3830-3838
Number of pages9
ISSN0021-972X
DOIs
Publication statusPublished - 1 Oct 2017

    Research areas

  • Adolescent, Child, Circadian Rhythm, Cross-Sectional Studies, Female, Follicle Stimulating Hormone, Humans, Longitudinal Studies, Luteinizing Hormone, Male, Puberty, Puberty, Precocious, Sensitivity and Specificity, Urinalysis, Young Adult, Clinical Trial, Journal Article

ID: 52109991