Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

No additive effect of combining sumatriptan and olcegepant in the GTN mouse model of migraine

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Prevalence of pre-cluster symptoms in episodic cluster headache: Is it possible to predict an upcoming bout?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypersensitivity to calcitonin gene-related peptide in chronic migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neurovascular contact plays no role in trigeminal neuralgia secondary to multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Real-life treatment of cluster headache in a tertiary headache center - results from the Danish Cluster Headache Survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Chronic migraine: Genetics or environment?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Changes in the gene expression profile during spontaneous migraine attacks

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Explicit Diagnostic Criteria for Transient Ischemic Attacks Used in the Emergency Department Are Highly Sensitive and Specific

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Despite recent advances in migraine treatment there is a need for therapies with higher clinical efficacy and/or fewer side effects. Triptans (5-HT1B/1D/1F agonists) are essential in the present treatment regime and gepants (CGRP-receptor antagonists) are recognized as effective in acute migraine treatment. Triptans and gepants have different mechanisms of action and here we tested the hypothesis that a combination of these drugs (sumatriptan and olcegepant) would result in an additive effect.

METHODS: Using the validated glyceryl trinitrate mouse model of migraine, we initially tested dose-response relationships of sumatriptan (0.1, 0.3, and 0.6 mg/kg IP) and olcegepant (0.25, 0.50, and 1.0 mg/kg IP) to find suitable high and low doses. Subsequently, we performed a combination study of the two drugs with a low and a high dose. All experiments were vehicle (placebo) controlled and blinded.

RESULTS: Sumatriptan significantly reduced glyceryl trinitrate-induced allodynia (F(4,54) = 13.51, p < 0.0001) at all doses. Olcegepant also reduced glyceryl trinitrate-induced allodynia (F(4,53) = 16.11, p < 0.0001) with the two higher doses being significantly effective. Combining 0.50 mg/kg olcegepant with 0.1 or 0.6 mg/kg sumatriptan did not have any improved effect compared to either drug alone (p > 0.50 on all days) in our mouse model.

CONCLUSION: Combining olcegepant and sumatriptan did not have an additive effect compared to single-drug treatment in this study. Triptan-gepant combinations will therefore most likely not improve migraine treatment. Nevertheless, further studies are necessary, and combinations should also be examined in patients with migraine.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume41
Issue number3
Pages (from-to)329-339
Number of pages11
ISSN0333-1024
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • additivity, CGRP, CGRP receptor antagonists, Headache, pain, triptans

ID: 61117409