Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

No abnormalities of intrinsic brain connectivity in the interictal phase of migraine with aura

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hospital readmissions following infections in dementia: a nationwide and registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Guidelines should be guidelines: Time to leave the terms "consensus" and "position" for other purposes

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Dementia increases mortality beyond effects of comorbid conditions: A national registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The chronobiology of migraine: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. PEARL study protocol: a real-world study of fremanezumab effectiveness in patients with chronic or episodic migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Erenumab prevents the occurrence of migraine attacks and not just migraine days: Post-hoc analyses of a phase III study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Guidelines of the International Headache Society for clinical trials with neuromodulation devices for the treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND AND PURPOSE: Functional neuroimaging studies have shown hyperresponsiveness of cortical areas to visual stimuli in migraine patients with aura outside of attacks. This may be a key feature in the initiation of aura episodes and possibly also migraine headache attacks. It is unknown if cortical dysfunction is present at rest, i.e. in the absence of any external stimuli. Functional magnetic resonance imaging is a powerful technique for evaluating resting state functional connectivity, i.e. coherence of brain activity across cerebral areas. The objective of this study was to investigate resting-state functional brain connectivity in migraineurs with aura outside of attacks using functional magnetic resonance imaging.

METHODS: Forty patients suffering from migraine with visual aura and 40 individually age and gender matched healthy controls with no history or family history of migraine were investigated. Following advanced denoising, the data were analyzed both in a hypothesis-driven fashion, testing for abnormalities involving 27 different brain areas of potential relevance to migraine with aura including the cortical visual areas, the amygdala and peri-aqueductal grey matter, and in a data-driven exploratory fashion (dual regression) in order to reveal any possible between-group differences of resting state networks. Age, gender, attack frequency and disease duration were included as nuisance variables.

RESULTS: No differences of functional connectivity were found between patients and controls.

CONCLUSIONS: The previously reported increased cortical hyperresponsivity in the interictal phase of migraine with aura is unlikely to be caused by abnormalities of intrinsic brain connectivity. The interictal migraine aura brain may be abnormally functioning only during exposure to external stimuli.

Original languageEnglish
JournalEuropean journal of neurology : the official journal of the European Federation of Neurological Societies
Volume22
Pages (from-to)702-10
ISSN1351-5101
DOIs
Publication statusPublished - 9 Jan 2015

ID: 44991851