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New drug candidates for depression - a nationwide population-based study

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  • L V Kessing
  • H C Rytgaard
  • T A Gerds
  • M Berk
  • C T Ekstrøm
  • P K Andersen
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OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers.

METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.

RESULTS: A total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low-dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident depression.

CONCLUSION: The findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population-based registers to systematically identify drugs with repurposing potential.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume139
Issue number1
Pages (from-to)68-77
Number of pages10
ISSN0001-690X
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • allopurinol, angiotensin, antidepressants, aspirin, depressive disorder, drug repurposing, inflammation, NSAID, statins, stress

ID: 56121007