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Rigshospitalet - a part of Copenhagen University Hospital
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New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis

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DOI

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  1. Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Challenges and opportunities for nephrology in Western Europe

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  4. Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

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The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The present review summarizes the complex regulation of FGF23 and the disturbed FGF23/Klotho system in chronic kidney disease (CKD). In addition to the reduced ability of the injured kidney to regulate plasma levels of FGF23, several CKD-related factors have been shown to stimulate FGF23 production. The high circulating FGF23 levels have detrimental effects on erythropoiesis, the cardio-vascular system and the immune system, all contributing to the disturbed system biology in CKD. Moreover, new factors secreted by the injured kidney and the uremic calcified vasculature play a role in the mineral and bone disorder in CKD and create a vicious pathological crosstalk.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume21
Issue number22
Pages (from-to)8810
Number of pages20
ISSN1661-6596
DOIs
Publication statusPublished - 2 Nov 2020

    Research areas

  • CKD-MBD, PTH, activin A, acute kidney failure, bone, calcitriol, calcium, chronic kidney failure, circadian rhythm, crosstalk, klotho, phosphate

ID: 61444679