Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

Research output: Contribution to journalJournal articleResearchpeer-review

  1. In utero exposure to maternal stressful life events and risk of polycystic ovary syndrome in the offspring: The Raine Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A systematic review and meta-analysis on the association between ICSI and chromosome abnormalities

    Research output: Contribution to journalReviewResearchpeer-review

  4. Parenthood among men diagnosed with cancer in childhood and early adulthood: trends over time in a Danish national cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Women show increased risk of depressive symptoms during hormonal transition phases. The risk mechanisms may include changes in mood in response to fluctuating ovarian hormones moderated by predisposing risk factors for mood disorders, such as personality trait Neuroticism.

METHODS: A pooled sample of 92 mentally healthy women (28.3 ± 7.1, mean age ± SD) from two independent cohorts run in our lab, using gonadotropin-releasing hormone agonist (GnRHa) experimentally (n = 28) compared to placebo (n = 27) and as part in vitro fertilization (n = 37), were extracted from the Center for Integrated Molecular Brain Imaging database. All women filled in questionnaires of trait Neuroticism from the NEO personality Inventory-Revised (NEO PI-R) at baseline and self-reported levels of mood disturbances with the Profile of Mood States (POMS) daily during 14 days of GnRHa intervention or placebo. Effects of intervention by trait Neuroticism on serial daily reports of mood disturbances were examined using mixed model analyses.

RESULTS: Personality trait Neuroticism significantly modulated daily mood responses to GnRHa, but not placebo. Women with high and low scores on trait Neuroticism at baseline experienced more pronounced changes in mood when exposed to GnRHa, whereas women with medium trait Neuroticism scores remained relatively stable.

CONCLUSIONS: The susceptibility to hormone-triggered mood changes appears to depend upon women's general tendency to experience distress and destabilization of mood, as captured by personality trait Neuroticism. This could aid clinicians evaluate hormone-related vulnerability for mood disorders in women and may guide targeted prevention in reproductive care.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume99
Pages (from-to)251-256
Number of pages6
ISSN0306-4530
DOIs
Publication statusPublished - 1 Jan 2019

ID: 55573722