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Rigshospitalet - a part of Copenhagen University Hospital
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Nephrotic syndrome and pulmonary hypertension as complications of intravenous drug abuse

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  • Janany Mohan
  • Camilla J Nybø
  • Johnny Vegsundvåg
  • Borghild Roald
  • Ylian S Liem
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This case report discusses a patient with nephrotic syndrome, pulmonary hypertension, and repeated episodes of infections. He had a history of intravenous drug abuse. Kidney biopsy revealed the rare finding of numerous foam cells, mainly in glomeruli. The solvent used for the drugs is thought to be responsible for the foam cells. In line with previous reports, we suspect that the pulmonary hypertension is consistent with foam cells in pulmonary capillaries or fat embolism syndrome due to the intravenous administered drugs. Our case demonstrates that the use of intravenous drugs can lead to widely varying symptoms. Globally, the prevalence of substance abuse is increasing. Knowledge about their damaging effects is crucial in both clinical practice and anatomic pathology.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume128
Issue number8
Pages (from-to)506-510
Number of pages5
ISSN0903-4641
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • Adult, Biopsy, Foam Cells/pathology, Humans, Hypertension, Pulmonary/complications, Infections/complications, Kidney/pathology, Male, Nephrotic Syndrome/complications, Substance Abuse, Intravenous/complications, histopathology, patholgy, designer drugs, Bacteriology, nephrology

ID: 61112870