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Neonatal complications and neurophysiological development in twins - a long-term follow-up study

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@article{c16c5975d9894009b8a726645218186e,
title = "Neonatal complications and neurophysiological development in twins - a long-term follow-up study",
abstract = "Objectives: To investigate the association between neonatal complications and neurophysiological development in twins at 18 and 48-60 months of age.Methods: This was a secondary analysis of 841 Danish mono- and dichorionic diamniotic twins from a randomized controlled trial (PREDICT study), which included an assessment of the twin's neurophysiological development using the Ages and Stages Questionnaire (ASQ) that had been filled out by the parents at 18 and 48 or 60 months. The correlation within twin pairs was accounted for by the method of generalized estimating equation. Models were adjusted for maternal educational score and gestational age at delivery.Results: ASQ data were available for 823 children at 18 months and 425 children at 48 or 60 months. Low maternal educational score and preterm delivery <34 weeks were associated with a lower ASQ score at 48-60 months (-15.4 points (95%CI -26.4; -4.5) and -13.2 points (95%CI -23.8; -2.5), respectively). Neonatal sepsis and a compound of intraventricular hemorrhage, retinopathy of prematurity and necrotizing enterocolitis (IVH/ROP/NEC) were associated with lower ASQ score at 18 months (-15.3 points (95%CI -28.1; -2.5) and -30.8 points (95%CI -59.5; -2.1), respectively). Children with IVH/ROP/NEC had a lower ASQ score at 48-60 months (-34.2 points (95%CI -67.9; -0.6)). The associations were not specific to only one ASQ domain.Conclusion: Several neonatal complications are associated with poorer neurophysiological development in twins during childhood, even after adjustment for gestational age at delivery.",
keywords = "Ages and stages questionnaire, follow-up, neonatal complications, neurophysiological development, twins",
author = "Cathrine Vedel and Helle Larsen and Anni Holmskov and Andreasen, {Kirsten Riis} and Niels Uldbjerg and Jan Ramb and Birgit B{\o}dker and Lillian Skibsted and Lene Sperling and Lone Krebs and Helle Zingenberg and Lone Laursen and Christensen, {Jeanette Tranberg} and Ann Tabor and Line Rode",
year = "2020",
month = jan,
day = "27",
doi = "10.1080/14767058.2020.1718647",
language = "English",
journal = "Journal of Maternal-Fetal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",

}

RIS

TY - JOUR

T1 - Neonatal complications and neurophysiological development in twins - a long-term follow-up study

AU - Vedel, Cathrine

AU - Larsen, Helle

AU - Holmskov, Anni

AU - Andreasen, Kirsten Riis

AU - Uldbjerg, Niels

AU - Ramb, Jan

AU - Bødker, Birgit

AU - Skibsted, Lillian

AU - Sperling, Lene

AU - Krebs, Lone

AU - Zingenberg, Helle

AU - Laursen, Lone

AU - Christensen, Jeanette Tranberg

AU - Tabor, Ann

AU - Rode, Line

PY - 2020/1/27

Y1 - 2020/1/27

N2 - Objectives: To investigate the association between neonatal complications and neurophysiological development in twins at 18 and 48-60 months of age.Methods: This was a secondary analysis of 841 Danish mono- and dichorionic diamniotic twins from a randomized controlled trial (PREDICT study), which included an assessment of the twin's neurophysiological development using the Ages and Stages Questionnaire (ASQ) that had been filled out by the parents at 18 and 48 or 60 months. The correlation within twin pairs was accounted for by the method of generalized estimating equation. Models were adjusted for maternal educational score and gestational age at delivery.Results: ASQ data were available for 823 children at 18 months and 425 children at 48 or 60 months. Low maternal educational score and preterm delivery <34 weeks were associated with a lower ASQ score at 48-60 months (-15.4 points (95%CI -26.4; -4.5) and -13.2 points (95%CI -23.8; -2.5), respectively). Neonatal sepsis and a compound of intraventricular hemorrhage, retinopathy of prematurity and necrotizing enterocolitis (IVH/ROP/NEC) were associated with lower ASQ score at 18 months (-15.3 points (95%CI -28.1; -2.5) and -30.8 points (95%CI -59.5; -2.1), respectively). Children with IVH/ROP/NEC had a lower ASQ score at 48-60 months (-34.2 points (95%CI -67.9; -0.6)). The associations were not specific to only one ASQ domain.Conclusion: Several neonatal complications are associated with poorer neurophysiological development in twins during childhood, even after adjustment for gestational age at delivery.

AB - Objectives: To investigate the association between neonatal complications and neurophysiological development in twins at 18 and 48-60 months of age.Methods: This was a secondary analysis of 841 Danish mono- and dichorionic diamniotic twins from a randomized controlled trial (PREDICT study), which included an assessment of the twin's neurophysiological development using the Ages and Stages Questionnaire (ASQ) that had been filled out by the parents at 18 and 48 or 60 months. The correlation within twin pairs was accounted for by the method of generalized estimating equation. Models were adjusted for maternal educational score and gestational age at delivery.Results: ASQ data were available for 823 children at 18 months and 425 children at 48 or 60 months. Low maternal educational score and preterm delivery <34 weeks were associated with a lower ASQ score at 48-60 months (-15.4 points (95%CI -26.4; -4.5) and -13.2 points (95%CI -23.8; -2.5), respectively). Neonatal sepsis and a compound of intraventricular hemorrhage, retinopathy of prematurity and necrotizing enterocolitis (IVH/ROP/NEC) were associated with lower ASQ score at 18 months (-15.3 points (95%CI -28.1; -2.5) and -30.8 points (95%CI -59.5; -2.1), respectively). Children with IVH/ROP/NEC had a lower ASQ score at 48-60 months (-34.2 points (95%CI -67.9; -0.6)). The associations were not specific to only one ASQ domain.Conclusion: Several neonatal complications are associated with poorer neurophysiological development in twins during childhood, even after adjustment for gestational age at delivery.

KW - Ages and stages questionnaire

KW - follow-up

KW - neonatal complications

KW - neurophysiological development

KW - twins

U2 - 10.1080/14767058.2020.1718647

DO - 10.1080/14767058.2020.1718647

M3 - Journal article

C2 - 31986942

JO - Journal of Maternal-Fetal Medicine

JF - Journal of Maternal-Fetal Medicine

SN - 1476-7058

ER -

ID: 59155155