Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

National data on the early clinical use of non-invasive prenatal testing in public and private healthcare in Denmark 2013-2017

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Differentiated timing of induction for women with intrahepatic cholestasis of pregnancy - a historical cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Length of hospital stay after cesarean section in Denmark from 2004 to 2016: a national register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pregnancy loss. A 40-year nationwide assessment

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Human papilloma virus vaccination and its real-life efficacy

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Ida C B Lund
  • Olav B Petersen
  • Naja H Becher
  • Dorte L Lildballe
  • Finn S Jørgensen
  • Louise Ambye
  • Lillian Skibsted
  • Anja Ernst
  • Ann N Jensen
  • Christina Fagerberg
  • Charlotte Brasch-Andersen
  • Ann Tabor
  • Helle J Zingenberg
  • Pernille Nørgaard
  • Gitte J Almind
  • Else Marie Vestergaard
  • Ida Vogel
View graph of relations

INTRODUCTION: In Denmark, non-invasive prenatal testing (NIPT) has been used since 2013. We aimed to evaluate the early clinical use of NIPT in Danish public and private healthcare settings before NIPT became an integrated part of the national guidelines on prenatal screening and diagnosis in 2017.

MATERIAL AND METHODS: NIPT data were collected between March 2013 and June 2017 from national public registries and private providers. Results from follow-up samples (chorionic villi, amniotic fluid, postnatal blood or fetal tissue) were included from The Danish Cytogenetics Central Registry and indications and outcome from The Danish Fetal Medicine Database.

RESULTS: A total of 3,936 NIPT results were included in the study from public hospitals (n=3,463, 88.0%) and private clinics (n=473, 12.0%). The total number of prenatal tests was 19,713 during the study period: 20% was NIPT-analyses (n=3,936) and 80% invasive procedures (n=15,777). Twenty-five per cent of NIPTs in the private clinics were performed before gestational week 11+0, whereas NIPT in public settings was used only after combined first trimester screening (p<0.001). Regardless of indication, the national public sensitivity was 96.9% (CI 95%: 82.0-99.8%) for trisomy (T) 21, 100%(CI95%: 46.3-100%) for trisomy 18, 100%(CI 95%: 5.5-100%) for trisomy 13 and 87.0%(CI 95%: 74.5-92.4%) for any fetal chromosomal aberration. Forty-seven true positive NIPT results included cases of common aneuplodies (trisomy 21, n=31; trisomy 18, n=5, trisomy 13, n=1), sex chromosomal aberrations (n=7) and atypical chromosomal aberrations (n=3). One false negative NIPT result occurred (trisomy 21). Twenty-one out of 47(45%) cases with a true positive NIPT result resulted in live births by choice; eleven of these children had Down and four had Edwards Syndrome.

CONCLUSIONS: The total number of NIPT analyses was low compared to the number of invasive procedures in the implementation period. In contrast to the generally high termination rate after a positive result following invasive testing in Denmark, a high proportion of true positive NIPT-results from the public setting resulted in live births. NIPT may be an important risk-free alternative to invasive testing for a minority of women in the public setting who wish to use prenatal genetic testing for information only and not for reproductive decision-making.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Pages (from-to)E-pub
Publication statusE-pub ahead of print - 24 Nov 2020

ID: 61307440